Polarisation fluoroimmunoassay for quinine in serum and urine.

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dc.contributor.authorSidki, A Men_US
dc.contributor.authorAl-Abdulla, I Hen_US
dc.contributor.authorLandon, Jen_US
dc.contributor.authorRowell, F Jen_US
dc.date.accessioned2009-05-27T15:11:53Z
dc.date.available2009-05-27T15:11:53Z
dc.date.issued1987-06-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractThe development and validation of a polarisation fluoroimmunoassay for the antimalarial drug quinine is described. The assay is performed either by sequential addition of the reagents or by a single-reagent technique whereby the tracer and antibodies are premixed. Serum samples require pepsin digestion prior to assay while urine specimens are assayed directly. The reliability criteria of the assay are satisfactory and no cross-reaction is detected with quinidine (the optical isomer of quinine) or with common antimalarial drugs. The assay was applied to the measurement of quinine in urine specimens obtained from a single-dose pharmacokinetic study and the results correlated with those of the benzene extraction fluorescence method for quinine measurement.en_US
dc.description.affiliationDepartment of Chemical Pathology, St. Bartholomew's Hospital, London, U.K.en_US
dc.identifier.citationSidki AM, Al-Abdulla IH, Landon J, Rowell FJ. Polarisation fluoroimmunoassay for quinine in serum and urine. The Southeast Asian Journal of Tropical Medicine and Public Health. 1987 Jun; 18(2): 149-55en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/32168
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshAdulten_US
dc.subject.meshAntimalarials --blooden_US
dc.subject.meshCross Reactionsen_US
dc.subject.meshFluorescence Polarizationen_US
dc.subject.meshHumansen_US
dc.subject.meshKineticsen_US
dc.subject.meshMaleen_US
dc.subject.meshQuinidine --blooden_US
dc.subject.meshQuinine --blooden_US
dc.titlePolarisation fluoroimmunoassay for quinine in serum and urine.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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