Risk Assessment of the Fungicide Talius with the Active Substances Proquinazid

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dc.contributor.authorSverdrup, L. E.en_US
dc.contributor.authorBjørge, C.en_US
dc.contributor.authorEklo, O. M.en_US
dc.contributor.authorGrung, M.en_US
dc.contributor.authorKällqvist, T.en_US
dc.contributor.authorKlingen, I.en_US
dc.contributor.authorLåg, M.en_US
dc.contributor.authorRopstad, E.en_US
dc.contributor.authorRivedal, E.en_US
dc.contributor.authorRopstad, E.en_US
dc.contributor.authorØvrebø, S.en_US
dc.date.accessioned2023-07-14T08:08:13Z
dc.date.available2023-07-14T08:08:13Z
dc.date.issued2022-10
dc.description.abstractTalius is a new fungicide containing the new active substance proquinazid. Talius is a fungicide against cereal powdery mildew (Blumeria graminis) in cereals and grass seed. The risk assessment was finalized at a meeting Mai 29, 2012, by VKM’s Scientific Panel on plant protection products (VKM). VKM is in particular asked by the Norwegian Food Safety Authority to look at the following: The human health risk for operators related to the properties of the active substance and the product. o The effects seen in studies on dog and if these effects warrant a classification for chronic toxicity. o The oncogenic effects in liver and thyroid. o The establishment of reference values (ADI, AOEL and ARfD). o Dermal absorption. o The classification and labelling of the active substances and the product. • The fate and behaviour in the environment and the ecotoxical effects and risks with regard to the properties of Talius and proquinazid. VKM’s conclusion is as follows: Health: VKM concluded that a less serious effect (dose-related ocular discharge increase) was seen in dogs in both the 90 days study and 1 year-study. The opinion of the Panel is that cholangiocarcinomas is relevant for the classification of cancer and VKM is concerned about these effects. VKM proposes an NOAEL of 1.2 mg/kg bw/day for proquinazid based on the 2 year study with rats. VKM support: The proposed ADI value of 0.01 mg/kg bw/day. • The proposed AOEL value of 0.02 mg/kg bw/day. The proposed ARfD value of 0.2 mg/kg bw/day. • The proposed classification from The Norwegian Food Safety Authority. VKM supports The Norwegian Food and Safety Authority calculations for dermal absorption under Norwegian directions for use (2.6 times higher dilution). Environment: Proquinazid can be persistent under prevailing conditions in Norway and the Panel considers the results from the Finnish PEC calculator to be relevant for Norwegian conditions and expects that repeated annual applications may cause accumulation in soil up to an equilibrium level under Norwegian conditions.The potential for groundwater contamination from leaching of proquinazid and its metabolites are low. There are minimal risks for toxic effects of proquinazid to terrestrial organisms, sediment dwelling organisms, aquatic plants, and algae with the proposed application regime. For fish and invertebrates minimal risks are calculated provided that a 3 m buffer zone is used.en_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM), Det Norske Veritas, Norwayen_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM), Norwegian Enviroment Agency, Norwayen_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM), Norwegian Institute of Bioeconomy Research, Norwayen_US
dc.identifier.affiliationsUniversity of Oslo / Norwegian Scientific Committee for Food Safety (VKM), Norwegian Institute for Water Research, Norwayen_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM),Norwegian Institute of Public Health (FHI), Norway.f Norwegian Scientific Committee for Food Safety (VKM), Oslo University Hospital, Norwayen_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM), Norwegian University of Life Sciences, Norwayen_US
dc.identifier.affiliationsNorwegian Scientific Committee for Food Safety (VKM), National Institute of Occupational Health, Norway.en_US
dc.identifier.citationSverdrup L. E., Bjørge C., Eklo O. M., Grung M., Källqvist T., Klingen I., Låg M., Ropstad E., Rivedal E., Ropstad E., Øvrebø S.. Risk Assessment of the Fungicide Talius with the Active Substances Proquinazid. European Journal of Nutrition & Food Safety. 2022 Oct; 14(10): 4-6en_US
dc.identifier.issn2347-5641
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/219611
dc.languageenen_US
dc.publisherSciencedomain Internationalen_US
dc.relation.issuenumber10en_US
dc.relation.volume14en_US
dc.source.urihttps://doi.org/10.9734/ejnfs/2022/v14i1030531en_US
dc.subjectVKMen_US
dc.subjectassessmenten_US
dc.subjectNorwegian Scientific Committee for Food Safetyen_US
dc.subjectfungicideen_US
dc.titleRisk Assessment of the Fungicide Talius with the Active Substances Proquinaziden_US
dc.typeJournal Articleen_US
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