A SPINK1 gene mutation in a Thai patient with fibrocalculous pancreatic diabetes.

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dc.contributor.authorSnabboon, Thitien_US
dc.contributor.authorPlengpanich, Waneeen_US
dc.contributor.authorSridama, Vitayaen_US
dc.contributor.authorSunthornyothin, Saraten_US
dc.contributor.authorSuwanwalaikorn, Sompongseen_US
dc.contributor.authorKhovidhunkit, Weerapanen_US
dc.date.accessioned2009-05-27T16:10:26Z
dc.date.available2009-05-27T16:10:26Z
dc.date.issued2006-05-24en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractFibrocalculous pancreatitis diabetes (FCPD), a late stage of tropical chronic pancreatitis (TCP), is classified as a secondary cause of diabetes mellitus resulting from pancreatic exocrine dysfunction. The distinctive features of FCPD and TCP are young age at onset, presence of large intraductal pancreatic calculi, and reported mainly in tropical developing countries. Their etiology is still obscure, but the autodigestion due to aberrant intraductal activation of zymogens by trypsin is thought to be a primary common event. Recently, mutations in SPINKI gene encoding a pancreatic secretory trypsin inhibitor have been reported in association with an increased risk of pancreatitis. We describe a heterozygous mutation, IVS3+2 T>C, of SPINK1 gene in a young Thai female patient with typical presentation of FCPD. To our knowledge, this is the first report of the SPINK1 gene mutation in a FCPD patient in Southeast Asia.en_US
dc.description.affiliationDepartment of Internal Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. Thiti.S@chula.ac.then_US
dc.identifier.citationSnabboon T, Plengpanich W, Sridama V, Sunthornyothin S, Suwanwalaikorn S, Khovidhunkit W. A SPINK1 gene mutation in a Thai patient with fibrocalculous pancreatic diabetes. The Southeast Asian Journal of Tropical Medicine and Public Health. 2006 May; 37(3): 559-62en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/34590
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/2006_37_3/21-3790.pdfen_US
dc.subject.meshAdolescenten_US
dc.subject.meshCarrier Proteins --geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInsulin --therapeutic useen_US
dc.subject.meshMutationen_US
dc.subject.meshPancreatitis, Chronic --drug therapyen_US
dc.titleA SPINK1 gene mutation in a Thai patient with fibrocalculous pancreatic diabetes.en_US
dc.typeCase Reportsen_US
dc.typeJournal Articleen_US
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