Safety and efficacy of protamine after transcatheter aortic valve replacement
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Date
2024-10
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Transfemoral Trans-catheter Aortic Valve Replacement (TF-TAVR) is a safe alternative to surgical aortic valve replacement (SAVR). Protamine is used to reverse heparin and reduce post-TAVR bleeding, but concerns about risks like valve thrombosis and stroke remain. This systematic review and meta-analysis, following PRISMA guidelines, found no statistically significant difference in major bleeding complications between the protamine and control groups [(3.0 % vs. 14.4 %); RR: 0.56; P = 0.16]. No differences were noted in life-threatening bleeding, blood transfusions, 30-day mortality, or stroke. Protamine appears safe post-TAVR without increasing stroke risk, but its effectiveness in reducing bleeding needs further investigation through a multi- centric randomized study.
Description
Keywords
Protamine, Transfemoral Trans-catheter aortic valve, replacement, Vascular complications
Citation
Kumaraguruparan Lakshmi Durga, Anandaram Asuwin, Sambandam Kamalakkannan G., Chidambaram Yogapriya, Kidambi Bharath Raj, Karthikeyan Gautam Ganesan, Kasi Madhesh, Abdulkader Rizwan Suliankatchi, Ramesh Sankaran, Ramalingam Vadivelu, Rajendran Ravindran, Senguttuvan Nagendra Boopathy . Safety and efficacy of protamine after transcatheter aortic valve replacement. Indian Heart Journal. 2024 Oct; 76(5): 352-354