Evaluation of Diaphragmatic Thickness and Dysfunction by Ultrasonography in Mechanically Ventilated Children for Assessment of Extubation Success

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dc.contributor.authorVadivelu, Saranyaen_US
dc.contributor.authorKhera, Daisyen_US
dc.contributor.authorChoudhary, Bharaten_US
dc.contributor.authorToteja, Nishaen_US
dc.contributor.authorSureka, Biniten_US
dc.contributor.authorSingh, Kuldeepen_US
dc.contributor.authorSingh, Surjiten_US
dc.date.accessioned2023-08-25T06:39:56Z
dc.date.available2023-08-25T06:39:56Z
dc.date.issued2023-03
dc.description.abstractObjectives: This study aimed to evaluate diaphragm thickness (DT) and diaphragmatic thickening fraction (DTF) in mechanically ventilated children, and study the association of these measurements with extubation success. Methods: Consecutive children aged one month to 18 years, who required mechanical ventilation (MV) for more than 24 hours at our institution, were enrolled between April, 2019 to October, 2020. Ultrasonographic measurements of DT were documented, and DTF was calculated from baseline (within 24 hours of MV) until 14 days of MV, and up to three days post-extubation. Results: Of the 54 childrenenrolled, 40 underwent planned extubation trial, of which 9 (22.5%) had extubation failure. Pre-extubation and post-extubation DTF between children in extubation-success and extubation-failure groups were comparable (P=0.074). There was no significant difference in the diaphragm atrophy rate between the two groups (P=0.819). Binary logistic regression showed significantly decreased probability of successful extubation with total ventilation duration (P=0.012) and mean DTF% before extubation (P=0.033). Conclusion: Despite evidence of diaphragmatic atrophy in critically ill children receiving mechanical ventilation, there was no significant difference in DTF between extubation success and failure groups.en_US
dc.identifier.affiliationsDepartment of Pediatric, All India Institute of Medical Sciences (AIIMS), Jodhpur, Rajasthanen_US
dc.identifier.affiliationsDepartment of Pediatrics, AIIMS, Gorakhpur, Uttar Pradeshen_US
dc.identifier.affiliationsDepartment of Diagnostic and Interventional Radiology, AIIMS Jodhpur, Rajasthanen_US
dc.identifier.affiliationsDepartment of Pharmacology, AIIMS, Jodhpur, Rajasthan.en_US
dc.identifier.citationVadivelu Saranya, Khera Daisy, Choudhary Bharat, Toteja Nisha, Sureka Binit, Singh Kuldeep, Singh Surjit. Evaluation of Diaphragmatic Thickness and Dysfunction by Ultrasonography in Mechanically Ventilated Children for Assessment of Extubation Success. Indian Pediatrics. 2023 Mar; 60(3): 212-216en_US
dc.identifier.issn0079-6061
dc.identifier.issn0974-7559
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/225397
dc.languageenen_US
dc.publisherIndian Academy of Pediatricsen_US
dc.relation.issuenumber3en_US
dc.relation.volume60en_US
dc.source.urihttps://indianpediatrics.net/mar2023/212.pdfen_US
dc.subjectDiaphragm atrophyen_US
dc.subjectDiaphragmatic thickening fractionen_US
dc.subjectMechanical ventilation.en_US
dc.titleEvaluation of Diaphragmatic Thickness and Dysfunction by Ultrasonography in Mechanically Ventilated Children for Assessment of Extubation Successen_US
dc.typeJournal Articleen_US
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