Elliptical deep anterior lamellar keratoplasty in severe Acanthamoeba keratitis

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dc.contributor.authorWang, Haiouen_US
dc.contributor.authorJhanji, Vishalen_US
dc.contributor.authorYe, Congen_US
dc.contributor.authorRen, Yuepingen_US
dc.contributor.authorZheng, Qinxiangen_US
dc.contributor.authorLi, Jinyangen_US
dc.contributor.authorZhao, Zelinen_US
dc.contributor.authorChen, Weien_US
dc.date.accessioned2023-08-25T06:36:27Z
dc.date.available2023-08-25T06:36:27Z
dc.date.issued2023-03
dc.description.abstractAcanthamoeba keratitis (AK) is an intractable infection of the cornea. Penetrating keratoplasty is widely used for the management of severe AK but suffers from complications like graft rejection, endophthalmitis, and glaucoma. Herein, we aimed to describe the surgical technique and the results of elliptical deep anterior lamellar keratoplasty (eDALK) for the management of severe AK. In this retrospective case series, records of consecutive patients with AK poorly responsive to medical treatment who underwent eDALK from January 2012 to May 2020 were reviewed. The largest diameter of infiltration was ?8 mm and did not involve the endothelium. The recipient bed was made by an elliptical trephine, and big bubble or wet-peeling technique was performed. Postoperative best spectacle-corrected visual acuity, endothelial cell density, corneal topographic data, and complications were evaluated. Thirteen eyes of thirteen patients (eight men and five women, 45.54 ± 11.78 years old) were included in this study. The mean follow-up interval was 21.31 ± 19.59 months (range, 12–82 months). At the last follow-up, the mean best spectacle-corrected visual acuity was 0.35 ± 0.27 logarithm of the minimum angle of resolution. The mean refractive and topographic astigmatism were ? 3.21 ± 1.77 and 3.08 ± 1.14 D, respectively. Intraoperative perforation was encountered in one case and double anterior chambers occurred in two cases. One graft developed stromal rejection and one eye developed amoebic recurrence. eDALK can serve as the first-line surgical management of severe AK poorly responsive to medical treatment.en_US
dc.identifier.affiliationsNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, Chinaen_US
dc.identifier.affiliationsDepartment of Cornea, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United Statesen_US
dc.identifier.citationWang Haiou, Jhanji Vishal, Ye Cong, Ren Yueping, Zheng Qinxiang, Li Jinyang, Zhao Zelin, Chen Wei. Elliptical deep anterior lamellar keratoplasty in severe Acanthamoeba keratitis. Indian Journal of Ophthalmology. 2023 Mar; 71(3): 999-1004en_US
dc.identifier.issn1998-3689
dc.identifier.issn0301-4738
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/224915
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber3en_US
dc.relation.volume71en_US
dc.source.urihttps://doi.org/10.4103/ijo.IJO_1018_22en_US
dc.subjectAcanthamoeba keratitisen_US
dc.subjectcorneaen_US
dc.subjectdeep anterior lamellar keratoplastyen_US
dc.titleElliptical deep anterior lamellar keratoplasty in severe Acanthamoeba keratitisen_US
dc.typeJournal Articleen_US
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