Evaluation of efficacy of BIORAD D10TM testing system in detection of beta thalassaemia carrier

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dc.contributor.authorRoy, Debajyoti Singhaen_US
dc.contributor.authorBhattacharyya, Rijuen_US
dc.contributor.authorMukhopadhyay, Kaushiken_US
dc.contributor.authorBandopadhyay, Debasisen_US
dc.date.accessioned2020-11-18T09:57:59Z
dc.date.available2020-11-18T09:57:59Z
dc.date.issued2019-03
dc.description.abstractBackground: Hemoglobinopathies especially thalassaemia and its interaction with HbE and HbS are significant cause of morbidity and mortality in our country. With no feasible treatment, prevention of cases by carrier detection is the only option for successful reduction of the disease burden. VARIANT hemoglobin testing system BIORAD using principle of cation exchange chromatography has been in use and considered as gold standard for carrier detection. The purpose of this study is to compare the efficacy of a different, cheaper instrument; D10 by the same manufacturer BIORAD for carrier detection in beta thalassaemia.Methods: Patients diagnosed as beta thalassaemia carrier by VARIANT hemoglobin testing system (HbA2 value between 4.0-9.0) were retested using D10 instrument and checked for agreement.Results: There was good correlation between VARIANT and D-10 methods with Intraclass correlation coefficient 0.832 (95% Confidence Interval 0.756-0.884). Bland-Altman analysis showed mean bias of +0.3526 (95% CI -0.3958 to +1.101).Conclusions: Although further study is needed with larger sample size for assessment of sensitivity and specificity of D10 instrument, it is evident from this study that this instrument can be an effective and cheaper alternative of VARIANT hemoglobin testing system.en_US
dc.identifier.affiliationsDepartment of Pathology, College of medicine and Sagar Dutta Hospital, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, ESI-PGIMSR & ESIC Medical College, Joka, Kolkata, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, ESI-PGIMSR & ESIC Medical College, Joka, Kolkata, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Vivekananda Institute of Medical Sciences, Kolkata, West Bengal, Indiaen_US
dc.identifier.citationRoy Debajyoti Singha, Bhattacharyya Riju, Mukhopadhyay Kaushik, Bandopadhyay Debasis. Evaluation of efficacy of BIORAD D10TM testing system in detection of beta thalassaemia carrier. International Journal of Research in Medical Sciences. 2019 Mar; 7(3): 782-785en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/211216
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber3en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-6012.ijrms20190923en_US
dc.subjectBeta thalassaemiaen_US
dc.subjectBIORAD D10en_US
dc.subjectBIORAD varianten_US
dc.subjectCarrieren_US
dc.subjectDetectionen_US
dc.titleEvaluation of efficacy of BIORAD D10TM testing system in detection of beta thalassaemia carrieren_US
dc.typeJournal Articleen_US
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