Reduced exercise capacity in non-cystic fibrosis bronchiectasis.

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dc.contributor.authorSwaminathan, Soumyaen_US
dc.contributor.authorKuppurao, K Ven_US
dc.contributor.authorSomu, Nen_US
dc.contributor.authorVijayan, V Ken_US
dc.date.accessioned2003-07-28en_US
dc.date.accessioned2009-05-30T15:38:04Z
dc.date.available2003-07-28en_US
dc.date.available2009-05-30T15:38:04Z
dc.date.issued2003-07-28en_US
dc.description.abstractOBJECTIVE: Bronchiectasis not due to cystic fibrosis is usually a consequence of severe bacterial or tuberculous infection of the lungs, which is commonly seen in children in developing countries. Our aim was to study its functional sequelae and affect on work capacity in children. METHODS: Seventeen children (7-17 years of age) with clinical and radiological evidence of bronchiectasis of one or both lungs were studied at the Cardiopulmonary Unit of the Tuberculosis Research Centre. Pulmonary function tests including spirometry and lung volume measurements were performed. Incremental exercise stress test was done on a treadmill, and ventilatory and cardiac parameters were monitored. Control values were taken from a previous study. RESULTS: Children with bronchiectasis had lower forced vital capacity (FVC) (1.1 + 0.4 L versus 1.5 + 0.4 L, p = 0.003) and FEV1 (0.95 +/- 0.2 L versus 1.4 +/- 0.3 L, p < 0.002) compared to age- and sex-matched healthy controls. The patient group had significantly higher residual lung volumes (0.7 +/- 0.3 L versus 0.4 + 0.1 L, p < 0.02). At maximal exercise, they had lower aerobic capacity (28 +/- 6 ml/min/kg versus 38 +/- 5 ml/min/kg, p < 0.0001) and maximal ventilation (24 +/- 8 L/min versus 39 +/- 10 L/min, p < 0.001). At maximal exercise, while none of the controls desaturated, oxygen saturation fell below 88% in eight of 17 patients. CONCLUSION: The findings show that children and adolescents with non-cystic fibrosis bronchiectasis have abnormal pulmonary function and reduced exercise capacity. This is likely to interfere with their life as well as future work capacity. Efforts should be made to minimize lung damage in childhood by ensuring early diagnosis and instituting appropriate treatment of respiratory infections.en_US
dc.description.affiliationTuberculosis Research Centre, Mayor VR Ramanathan Road, Chetput, Chennai, India. doctorsoumya@yahoo.comen_US
dc.identifier.citationSwaminathan S, Kuppurao KV, Somu N, Vijayan VK. Reduced exercise capacity in non-cystic fibrosis bronchiectasis. Indian Journal of Pediatrics. 2003 Jul; 70(7): 553-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/83805
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshAdolescenten_US
dc.subject.meshBronchiectasis --physiopathologyen_US
dc.subject.meshChilden_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshExercise Toleranceen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshRespiratory Function Testsen_US
dc.subject.meshSpirometryen_US
dc.titleReduced exercise capacity in non-cystic fibrosis bronchiectasis.en_US
dc.typeJournal Articleen_US
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