Novel therapeutic approaches to squamous cell carcinoma of the head and neck using biologically targeted agents.

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dc.contributor.authorHarrington, K J
dc.contributor.authorKazi, R
dc.contributor.authorBhide, S A
dc.contributor.authorNewbold, K
dc.contributor.authorNutting, C M
dc.date.accessioned2013-01-15T08:56:50Z
dc.date.available2013-01-15T08:56:50Z
dc.date.issued2010-07
dc.description.abstractDespite significant improvements in the treatment and outcomes of patients with squamous cell carcinoma of the head and neck (SCCHN) that have resulted from technological advances in radiation delivery and the use of cytotoxic chemotherapy, there is still a pressing need for novel therapies. In the last two decades, our understanding of the molecular biological basis of cancer has provided us with a new framework for developing specific targeted therapies. It is likely that the next wave of developments will include active small molecule inhibitors of epidermal growth factor receptor (EGFR) (and other members of the c-erbB family of receptors), antiangiogenic agents, and drugs that can increase proapoptotic signaling in cancer cells. As with cetuximab, it is most likely that these new agents will first find a niche in the context of combination regimens with standard anticancer therapeutics.en_US
dc.identifier.citationHarrington K J, Kazi R, Bhide S A, Newbold K, Nutting C M. Novel therapeutic approaches to squamous cell carcinoma of the head and neck using biologically targeted agents. Indian Journal of Cancer. 2010 Jul-Sept; 47(3): 248-259.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/144347
dc.language.isoenen_US
dc.source.urihttps://www.indianjcancer.com/article.asp?issn=0019-509X;year=2010;volume=47;issue=3;spage=248;epage=259;aulast=Harringtonen_US
dc.subjectBiologically targeted agentsen_US
dc.subjectepidermal growth factor receptoren_US
dc.subjectEGFR inhibitorsen_US
dc.subjecttyrosine kinase inhibitorsen_US
dc.subject.meshAngiogenesis Inhibitors --therapeutic use
dc.subject.meshAntibodies, Monoclonal --pharmacology
dc.subject.meshAntibodies, Monoclonal --therapeutic use
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols --therapeutic use
dc.subject.meshApoptosis --drug effects
dc.subject.meshBiological Therapy --trends
dc.subject.meshCarcinoma, Squamous Cell --drug therapy
dc.subject.meshCarcinoma, Squamous Cell --metabolism
dc.subject.meshCarcinoma, Squamous Cell --pathology
dc.subject.meshChemotherapy, Adjuvant
dc.subject.meshDrug Discovery
dc.subject.meshHead and Neck Neoplasmsdrug therapy
dc.subject.meshHead and Neck Neoplasms --metabolism
dc.subject.meshHead and Neck Neoplasms --pathology
dc.subject.meshHumans
dc.subject.meshIntracellular Signaling Peptides and Proteins --agonists
dc.subject.meshReceptor, Epidermal Growth Factor --antagonists & inhibitors
dc.titleNovel therapeutic approaches to squamous cell carcinoma of the head and neck using biologically targeted agents.en_US
dc.typeArticleen_US
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