Novel therapeutic approaches to squamous cell carcinoma of the head and neck using biologically targeted agents.
dc.contributor.author | Harrington, K J | |
dc.contributor.author | Kazi, R | |
dc.contributor.author | Bhide, S A | |
dc.contributor.author | Newbold, K | |
dc.contributor.author | Nutting, C M | |
dc.date.accessioned | 2013-01-15T08:56:50Z | |
dc.date.available | 2013-01-15T08:56:50Z | |
dc.date.issued | 2010-07 | |
dc.description.abstract | Despite significant improvements in the treatment and outcomes of patients with squamous cell carcinoma of the head and neck (SCCHN) that have resulted from technological advances in radiation delivery and the use of cytotoxic chemotherapy, there is still a pressing need for novel therapies. In the last two decades, our understanding of the molecular biological basis of cancer has provided us with a new framework for developing specific targeted therapies. It is likely that the next wave of developments will include active small molecule inhibitors of epidermal growth factor receptor (EGFR) (and other members of the c-erbB family of receptors), antiangiogenic agents, and drugs that can increase proapoptotic signaling in cancer cells. As with cetuximab, it is most likely that these new agents will first find a niche in the context of combination regimens with standard anticancer therapeutics. | en_US |
dc.identifier.citation | Harrington K J, Kazi R, Bhide S A, Newbold K, Nutting C M. Novel therapeutic approaches to squamous cell carcinoma of the head and neck using biologically targeted agents. Indian Journal of Cancer. 2010 Jul-Sept; 47(3): 248-259. | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/144347 | |
dc.language.iso | en | en_US |
dc.source.uri | https://www.indianjcancer.com/article.asp?issn=0019-509X;year=2010;volume=47;issue=3;spage=248;epage=259;aulast=Harrington | en_US |
dc.subject | Biologically targeted agents | en_US |
dc.subject | epidermal growth factor receptor | en_US |
dc.subject | EGFR inhibitors | en_US |
dc.subject | tyrosine kinase inhibitors | en_US |
dc.subject.mesh | Angiogenesis Inhibitors --therapeutic use | |
dc.subject.mesh | Antibodies, Monoclonal --pharmacology | |
dc.subject.mesh | Antibodies, Monoclonal --therapeutic use | |
dc.subject.mesh | Antineoplastic Combined Chemotherapy Protocols --therapeutic use | |
dc.subject.mesh | Apoptosis --drug effects | |
dc.subject.mesh | Biological Therapy --trends | |
dc.subject.mesh | Carcinoma, Squamous Cell --drug therapy | |
dc.subject.mesh | Carcinoma, Squamous Cell --metabolism | |
dc.subject.mesh | Carcinoma, Squamous Cell --pathology | |
dc.subject.mesh | Chemotherapy, Adjuvant | |
dc.subject.mesh | Drug Discovery | |
dc.subject.mesh | Head and Neck Neoplasmsdrug therapy | |
dc.subject.mesh | Head and Neck Neoplasms --metabolism | |
dc.subject.mesh | Head and Neck Neoplasms --pathology | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Intracellular Signaling Peptides and Proteins --agonists | |
dc.subject.mesh | Receptor, Epidermal Growth Factor --antagonists & inhibitors | |
dc.title | Novel therapeutic approaches to squamous cell carcinoma of the head and neck using biologically targeted agents. | en_US |
dc.type | Article | en_US |