Efficacy of Advanced Odomos repellent cream (N, N-diethyl-benzamide) against mosquito vectors.

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dc.contributor.authorMittal, P K
dc.contributor.authorSreehari, U
dc.contributor.authorRazdan, R K
dc.contributor.authorDash, A P
dc.contributor.authorAnsari, M A
dc.date.accessioned2011-12-05T09:01:36Z
dc.date.available2011-12-05T09:01:36Z
dc.date.issued2011-04
dc.description.abstractBackground & objectives: Repellents are commonly used personal protection measures to avoid mosquito bites. In the present study, Advanced Odomos cream (12% N, N-diethyl-benzamide) was tested for its efficacy against mosquitoes in comparison to DEET (N,N-diethyl-3-methyl benzamide). Methods: Bioassays were conducted to assess the repellency of Advanced Odomos and DEET creams against Anopheles stephensi and Aedes aegypti. Their efficacy was tested on human volunteers applied with different concentrations of test creams ranging from 1 to 12 mg/cm2 and by exposing them to mosquitoes at hourly intervals. Field evaluation was also carried out to test the duration of protection of the test creams against Anopheles and Aedes mosquitoes during whole night and day time collections, respectively on human volunteers. Mosquito collections were done using torch light and aspirator. Results: Complete (100%) protection was achieved at 10 mg/cm2 cream formulation of Advanced Odomos (1.2 mg a.i/cm2) dose against An. stephensi and 12 mg/cm2 (1.44 mg a.i./cm2) against Ae. aegypti on human baits. There was no statistically significant differences in per cent protection against mosquito bites between Advanced o0 domos and DEET cream (P>0.05) in respective doses. Complete protection up to 11 h was observed against Anopheles mosquitoes during whole night collections and up to 6 h against Ae. aegypti in day time collections. No adverse reactions such as itching, irritation, vomiting, nausea, etc. were reported by the volunteers. Interpretation & conclusions: Advanced odomos cream applied at 10 mg/cm2 concentration provided 100% protection from Anopheles mosquitoes up to 11 h whereas about 6 h protection was recorded against Ae. aegypti. The laboratory and field trials indicate that for longer protection against Anopheles mosquitoes 10 mg/cm2 will be appropriate and in case of Ae. aegypti more than 10 mg/cm2 application is required for complete protection. In conclusion, the Advanced Odomos cream was comparable to the known repellent cream DEET for prolonged protection against malaria and dengue vectors.en_US
dc.identifier.citationMittal P K, Sreehari U, Razdan R K, Dash A P, Ansari M A. Efficacy of Advanced Odomos repellent cream (N, N-diethyl-benzamide) against mosquito vectors. Indian Journal of Medical Research. 2011 Apr; 133(4): 426-430.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/135670
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103177/en_US
dc.subjectAdvanced odomosen_US
dc.subjectAnopheles culicifaciesen_US
dc.subjectAn. stephensien_US
dc.subjectAedes aegyptien_US
dc.subjectDEETen_US
dc.subjectrepellencyen_US
dc.subject.lcshAdministration, Topical
dc.subject.meshAedes
dc.subject.meshAnimals
dc.subject.meshAnopheles
dc.subject.meshCulicidae
dc.subject.meshDEET --administration & dosage
dc.subject.meshDEET --analogs & derivatives
dc.subject.meshHumans
dc.subject.meshInsect Bites and Stings --prevention & control
dc.subject.meshInsect Repellents --administration & dosage
dc.subject.meshInsect Vectors
dc.titleEfficacy of Advanced Odomos repellent cream (N, N-diethyl-benzamide) against mosquito vectors.en_US
dc.typeArticleen_US
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