A randomized controlled trial on lactoferrin versus ferrous sulphate for the treatment of mild to moderate iron deficiency anaemia in pregnancy

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dc.contributor.authorGawai, Swatien_US
dc.contributor.authorFonseca, Michelleen_US
dc.contributor.authorKapote, Deepalien_US
dc.date.accessioned2020-10-16T08:02:13Z
dc.date.available2020-10-16T08:02:13Z
dc.date.issued2020-02
dc.description.abstractBackground: One of the important factors associated with maternal and foetal complications during pregnancy is Anaemia. Various oral preparations of iron are available, and each has different bioavailability, efficacy and adverse effects. Lactoferrin is a naturally existing iron-binding multifunctional glycoprotein, and a member of a transferrin family, thus belonging to those proteins capable of binding and transferring iron. Lactoferrin has considerably less gastrointestinal side effects than ferrous sulfate and is very useful as well as promising alternative to ferrous sulphate.Methods: Prospective randomized controlled study. Total 100 females with 24 to 36 weeks of pregnancy with haemoglobin between 8 to 10 grams were included out of which 50 patients were given ferrous sulphate 200 mg BD and 50 patients were given lactoferrin 250 mg BD daily for 8 weeks. Various haematological parameters and the adverse effects of both the drugs were studied at registration, 4 weeks and 8 weeks and compared.Results: Thus, after this study authors can say that the rise in haemoglobin with lactoferrin was 1.58 g/dl while with ferrous sulphate it was 1.67 g/dl at 8 weeks. Adverse effects were much lesser in Group A taking lactoferrin compared to Group B.Conclusions: Thus, lactoferrin has the advantage over ferrous sulphate in having   less side effects and increasing the compliance and thus the efficacy of the drug compared to ferrous sulphate.en_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, LTMMC and Sion Hospital Mumbai, Maharashtra, Indiaen_US
dc.identifier.citationGawai Swati, Fonseca Michelle, Kapote Deepali. A randomized controlled trial on lactoferrin versus ferrous sulphate for the treatment of mild to moderate iron deficiency anaemia in pregnancy. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2020 Feb; 9(2): 562-566en_US
dc.identifier.issn2320-1770
dc.identifier.issn2320-1789
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/207399
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber2en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-1770.ijrcog20200336en_US
dc.subjectAnaemiaen_US
dc.subjectFerrous sulphateen_US
dc.subjectHaemoglobinen_US
dc.subjectIron deficiency anaemiaen_US
dc.subjectLactoferrinen_US
dc.subjectPregnancyen_US
dc.subjectSerum Ironen_US
dc.subjectTotal iron binding capacityen_US
dc.titleA randomized controlled trial on lactoferrin versus ferrous sulphate for the treatment of mild to moderate iron deficiency anaemia in pregnancyen_US
dc.typeJournal Articleen_US
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