Propofol vs isoflurane for neurosurgical anesthesia in Thai patients.

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dc.contributor.authorIttichaikulthol, Wen_US
dc.contributor.authorPausawasdi, Sen_US
dc.contributor.authorSrichintai, Pen_US
dc.contributor.authorSarnvivad, Pen_US
dc.date.accessioned2009-05-27T18:57:52Z
dc.date.available2009-05-27T18:57:52Z
dc.date.issued1997-07-01en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractSixty Thai patients, ASA class I-II, Glasgow coma score of 15 undergoing elective intracranial surgery were randomly assigned to 2 groups. In group I, 30 patients were induced with thiopental 3-5 mg/kg, intubation with succinylcholine 1-2 mg/kg and then maintained with 60 per cent N2O in O2, isoflurane and vecuronium as a muscle relaxant. In group II, 30 patients received fentanyl 50 micrograms, propofol 1.0-2.5 mg/kg for induction and vecuronium 0.08 mg/kg for intubation then maintained with 60 per cent N2O in O2, continuous infusion of propofol 2-12 mg/kg/h and vecuronium as a muscle relaxant. Controlled ventilation in both groups was set to maintain PET CO2 in the range of 28-35 mmHg. 3 patients (1 in group I and 2 in group II) were excluded from the study due to surgical problems. There was no statistical difference in age, sex, ASA status, weight, duration of anesthesia. Group II had a more stable systolic BP, Diastolic BP and Pulse rate than Group I during induction and emergence from anesthesia. Glasgow coma scores in the recovery period, Group II had higher scores than Group I at 5 and 15 minutes but not at 30 minutes. Mean recovery times (eye opening) was 14.03 +/- 4.85 minutes in group I which is significantly different from 10 +/- 5.17 minutes in group II. The cost of anesthesia in group II was 1.3 times that of group I. In conclusion, although neurosurgical anesthesia for Thai patients with fentanyl-propofol technique produces more stable blood pressure during intubation and emergence, rapid recovery from anesthesia and a higher Glasgow coma score, the cost of anesthesia is more expensive. Furthermore, this technique is more difficult and needs more experience.en_US
dc.description.affiliationDepartment of Anesthesiology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.en_US
dc.identifier.citationIttichaikulthol W, Pausawasdi S, Srichintai P, Sarnvivad P. Propofol vs isoflurane for neurosurgical anesthesia in Thai patients. Journal of the Medical Association of Thailand. 1997 Jul; 80(7): 454-60en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/40200
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAnalysis of Varianceen_US
dc.subject.meshAnesthesia Recovery Perioden_US
dc.subject.meshAnesthetics, Inhalation --administration & dosageen_US
dc.subject.meshAnesthetics, Intravenous --administration & dosageen_US
dc.subject.meshBlood Pressure --drug effectsen_US
dc.subject.meshChi-Square Distributionen_US
dc.subject.meshFemaleen_US
dc.subject.meshFentanyl --administration & dosageen_US
dc.subject.meshGlasgow Coma Scaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIsoflurane --administration & dosageen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeurosurgeryen_US
dc.subject.meshPropofol --administration & dosageen_US
dc.subject.meshThailanden_US
dc.subject.meshThiopental --administration & dosageen_US
dc.titlePropofol vs isoflurane for neurosurgical anesthesia in Thai patients.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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