Flowcytometric evidence of platelet activation in patients on aspirin following myocardial infarction.

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dc.contributor.authorGhosh, Ken_US
dc.contributor.authorKhare, Aen_US
dc.contributor.authorShetty, Sen_US
dc.contributor.authorNair, Sen_US
dc.contributor.authorKulkarni, Ben_US
dc.contributor.authorMohanty, Den_US
dc.date.accessioned2006-03-08en_US
dc.date.accessioned2009-06-03T05:30:31Z
dc.date.available2006-03-08en_US
dc.date.available2009-06-03T05:30:31Z
dc.date.issued2006-03-08en_US
dc.description.abstractBACKGROUND: Following a myocardial infarction, patients are usually started on long term antiplatelet therapy with aspirin in a dose of 80-150 mg/day. However, there are no quick and easy methods to assess the efficacy of the antiplatelet activity of aspirin. METHODS: We studied 60 consecutive patients (men, < 40 years of age) 8-10 weeks after they had had acute myocardial infarction. These patients were receiving 100 mg aspirin daily orally with or without b-blockers. We measured P-selectin expression and fibrinogen binding by flowcytometry at least 3 times over a period of 2 years in all the patients. We also studied 100 age- and sex-matched controls. RESULTS: Of the 60 patients, 30 (50%) showed both increased P-selectin and fibrinogen binding by platelets, suggesting platelet activation. Fourteen other patients had increased fibrinogen binding but normal P-selectin expression. Sixteen patients and all the controls had normal results of both tests. CONCLUSION: Our data show evidence of platelet activation in at least 50% of patients receiving 100 mg of aspirin daily. Flowcytometry for P-selectin expression and fibrinogen binding to platelets can be used to monitor antiplatelet therapy with aspirin following acute myocardial infarction.en_US
dc.description.affiliationInstitute of Immunohaematology (ICMR), 13th floor, New Building, K.E.M. Hospital, Parel, Mumbai 400012, Maharashtra. kanjakshaghosh@hotmail.comen_US
dc.identifier.citationGhosh K, Khare A, Shetty S, Nair S, Kulkarni B, Mohanty D. Flowcytometric evidence of platelet activation in patients on aspirin following myocardial infarction. National Medical Journal of India. 2006 Mar-Apr; 19(2): 73-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/118416
dc.language.isoengen_US
dc.source.urihttps://www.nmji.inen_US
dc.subject.meshAcute Diseaseen_US
dc.subject.meshAdulten_US
dc.subject.meshAspirin --administration & dosageen_US
dc.subject.meshAtherosclerosis --prevention & controlen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshCyclooxygenase Inhibitors --administration & dosageen_US
dc.subject.meshDrug Monitoringen_US
dc.subject.meshFemaleen_US
dc.subject.meshFibrinogen --drug effectsen_US
dc.subject.meshFlow Cytometryen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMyocardial Infarction --drug therapyen_US
dc.subject.meshP-Selectin --drug effectsen_US
dc.subject.meshPlatelet Activation --drug effectsen_US
dc.subject.meshPlatelet Aggregation Inhibitors --administration & dosageen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRisk Factorsen_US
dc.titleFlowcytometric evidence of platelet activation in patients on aspirin following myocardial infarction.en_US
dc.typeJournal Articleen_US
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