Corneal manifestations and treatment among patients with COVID-19-associated rhino-orbito-cerebral mucormycosis

Simple item page
dc.contributor.authorYadav, Rekhaen_US
dc.contributor.authorMadan, Siddharthen_US
dc.contributor.authorRohatgi, Jollyen_US
dc.contributor.authorSahu, Pramod Kumaren_US
dc.contributor.authorDas, Shuklaen_US
dc.contributor.authorTandon, Anupamaen_US
dc.contributor.authorRai, Pujaen_US
dc.contributor.authorVerma, Priyaen_US
dc.contributor.authorSingh, Jubinen_US
dc.contributor.authorBajaj, Ishitaen_US
dc.date.accessioned2023-08-25T06:35:49Z
dc.date.available2023-08-25T06:35:49Z
dc.date.issued2023-01
dc.description.abstractPurpose: TO report the corneal manifestations in patients with COVID?19?associated rhino?orbito?cerebral mucormycosis (ROCM). Methods: This study was a retrospective, observational, and record?based analysis of patients of ROCM with corneal involvement. Results: A total of 220 patients were diagnosed with ROCM over a period of 3 months. Thirty?two patients had developed corneal manifestations. The mean age at diagnosis was 52.84 ± 12.8 years. The associated risk factors were systemic mucormycosis, uncontrolled diabetes, recent COVID?19 infection, and injudicious use of systemic steroids. Twenty?nine patients were known diabetics, 32 had recent COVID?19 infection, and 13 gave a history of injudicious use of steroids. The right eye (RE) was affected in nine patients, the left eye (LE) in 20 patients, and both eyes in three patients. Nine patients had a round?oval corneal ulcer. One patient each had a perforated corneal ulcer with uveal prolapse, sealed perforated corneal ulcer, spontaneously healed limbal perforation, diffuse corneal haze with hyphemia, panophthalmitis, diffuse corneal stromal abscess, limbal ischemia, anterior uveitis with posterior synechiae, inferior corneal facet, and filamentary keratitis. Three patients each had a corneal melt and inferior conjunctival xerosis with chemosis. Orbital exenteration was performed in six patients. Five patients with corneal ulcers healed. Topical eye drops of amphotericin (0.5 mg/ ml) cycloplegic, antiglaucoma medications, and lubricant eye drops were started along with systemic antifungals. Conclusion: Central corneal ulcer was the most common manifestation of mucormycosis. A concentration as low as 0.5 mg/ml of amphotericin eye drops was effective in the treatment.en_US
dc.identifier.affiliationsDepartment of Ophthalmology, University College of Medical Sciences and Associated GTB Hospital, Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, University College of Medical Sciences and Associated GTB Hospital, Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Radiology, University College of Medical Sciences and Associated GTB Hospital, Delhi, Indiaen_US
dc.identifier.citationYadav Rekha, Madan Siddharth, Rohatgi Jolly, Sahu Pramod Kumar, Das Shukla, Tandon Anupama, Rai Puja, Verma Priya, Singh Jubin, Bajaj Ishita. Corneal manifestations and treatment among patients with COVID-19-associated rhino-orbito-cerebral mucormycosis. Indian Journal of Ophthalmology. 2023 Jan; 71(1): 101-108en_US
dc.identifier.issn1998-3689
dc.identifier.issn0301-4738
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/224820
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber1en_US
dc.relation.volume71en_US
dc.source.urihttps://doi.org/10.4103/ijo.IJO_1477_22en_US
dc.subjectCorneaen_US
dc.subjectcorneal ulceren_US
dc.subjectCOVID?19en_US
dc.subjectexposure keratopathyen_US
dc.subjectpanophthalmitisen_US
dc.subjectrhino?orbito?cerebral mucormycosisen_US
dc.titleCorneal manifestations and treatment among patients with COVID-19-associated rhino-orbito-cerebral mucormycosisen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
IJO2023v71n1p101.pdf
Size:
2.4 MB
Format:
Adobe Portable Document Format
Download
Collections
Indian Journal of Ophthalmology