In vitro susceptibility pattern of Tigecycline against MRSA, ESBL producing Escherichia coli, Klebsiella species and Acinetobacter isolates in a rural tertiary care hospital.
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Date
2015-01
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Abstract
Background: Tigecycline is the first commercially available
glycycline, derivatives of the tetracycline antibiotics, having
enhanced activity against various pathogens. In vitro activity has
been demonstrated against multi drug resistant Gram positive
and Gram negative pathogens like MRSA, ESBL producing
Esch.coli and Klebsiella spp. and Acinetobacter Objective: To
determine Tigecycline in vitro susceptibility pattern in MRSA, ESBL
producing Esch.coli and Klebsiella spp. and Acinetobacter spp.
Material and Methods: Investigations were carried out from
August 2012-January 2014 to detect MRSA,ESBL producing
Escherichia coli and Klebsiella spp. as well as Acinetobacter spp.
by using a standard protocols and Tigecycline in-vitro
susceptibility testing was done by Kirby Bauer Disc diffusion
method and it’s MIC value against resistant isolates was
evaluated.Statistical analysis was done by Fishers extract
method.
Result: Out of 107 Staphylococcus aureus isolates 52(48.59%)
were MRSA, none of them showed resistance to Tigecycline. Out
of 82 Esch.coli isolates 14 (i.e 17.07%) were ESBL producers, none
of them showed resistance to Tigecycline.Out of 67 Klebsiella
isolates 21 (i.e 31.34%) were ESBL producers out of which only 1
(i.e 4.76%) was resistant to Tigecycline.Out of 19 Acinetobacter
spp.isolated 3 (i.e 15.78%) were resistant to Tigecycline. The MIC
range for ESBL producing Eschcoli, Klebsiella spp., MRSA and
acinetobacter spp were 0.14-0.45 μg/ml,0.25-2.4 μg/ml,0.12-0.26
μg/ml, 1-3.2 μg/ml respectively.
Conclusion: The results of the study confirm the excellent in vitro
activity of Tigecycline against Gram positive and Gram negative
multidrug resistant pathogens.
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Keywords
Tigecycline, susceptibility, MRSA, ESBL producing Klebsiella spp, acinetobacter
Citation
Nandi P, Kumar S, Biswas T, Mitra G, Chejara SK, Roy S. In vitro susceptibility pattern of Tigecycline against MRSA, ESBL producing Escherichia coli, Klebsiella species and Acinetobacter isolates in a rural tertiary care hospital. International Journal of Medical and Dental Sciences. 2015 Jan; 4(1): 607-617.