Amelioration of cisplatin induced nephrotoxicity in Swiss albino mice by Rubia cordifolia extract.

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dc.contributor.authorJoy, Jishaen_US
dc.contributor.authorNair, Cherupally Krishnan Krishnanen_US
dc.date.accessioned2008-07-17en_US
dc.date.accessioned2009-06-01T16:21:39Z
dc.date.available2008-07-17en_US
dc.date.available2009-06-01T16:21:39Z
dc.date.issued2008-07-17en_US
dc.description.abstractBACKGROUND: Cisplatin is one of the most effective chemotherapeutics against a wide range of cancers including head, neck, ovarian and lung cancers. But its usefulness is limited by its toxicity to normal tissues, including cells of the kidney proximal tubule. The purpose of the present study is to investigate whether the hydro-alcoholic extract of Rubia cordifolia could decrease the intensity of toxicity in Swiss albino mice. MATERIALS AND METHODS: Cisplatin at a dose of 12 mg/kg body wt was administered intraperitoneally to Swiss albino mice. Another set of animals was given hydro-alcoholic extract of Rubia cordifolia at different doses along with cisplatin treatment. The antioxidant levels, serum creatinine, serum urea etc. were analyzed. Results: The extract could significantly decrease the cisplatin induced nephrotoxicity as inferred from the tissue antioxidant status in the drug administered animals. Remarkable change was observed in serum creatinine and urea levels. Lipid peroxidation in the kidney and liver tissues was also considerably reduced in Rubia cordifolia extract treated animals. CONCLUSION: Hydro-alcoholic extracts of Rubia cordifolia are effective in reducing the renal damage caused by the cancer chemotherapeutic drug cisplatin. Since Rubia cordifolia has been in use as an important ingredient in the traditional Ayurvedic system of medicine, it could be safe and beneficial to use this herbal extract as an adjuvant to ameliorate renal damage in patients undergoing cancer chemotherapy with cisplatin.en_US
dc.description.affiliationDepartment of Radiation Biology, Amala Cancer Research Centre, Amala Nagar, Thrissur-680 555, Kerala, India. ckknair@yahoo.comen_US
dc.identifier.citationJoy J, Nair CK. Amelioration of cisplatin induced nephrotoxicity in Swiss albino mice by Rubia cordifolia extract. Journal of Cancer Research and Therapeutics. 2008 Jul-Sep; 4(3): 111-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/111495
dc.language.isoengen_US
dc.source.urihttps://www.cancerjournal.neten_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntineoplastic Agents --adverse effectsen_US
dc.subject.meshCatalase --drug effectsen_US
dc.subject.meshCisplatin --adverse effectsen_US
dc.subject.meshGlutathione --drug effectsen_US
dc.subject.meshKidney Diseases --chemically induceden_US
dc.subject.meshLipid Peroxidation --drug effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshNeoplasms --drug therapyen_US
dc.subject.meshPhytotherapyen_US
dc.subject.meshPlant Extracts --therapeutic useen_US
dc.subject.meshRubiaen_US
dc.subject.meshSuperoxide Dismutase --drug effectsen_US
dc.titleAmelioration of cisplatin induced nephrotoxicity in Swiss albino mice by Rubia cordifolia extract.en_US
dc.typeJournal Articleen_US
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