Peritoneal Cytology in the Staging Process of Gastric Carcinoma
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Date
2024-09
Journal Title
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Publisher
Society for Health Care & Research Development
Abstract
Background: Peritoneal carcinomatosis is one of the patterns of recurrence in patients with gastric cancer. The prognosis of patients with advanced gastric cancer invading the gastric serosa because of the high incidence of peritoneal recurrence. Recurrence with this pattern is most likely caused by the presence of free cancer cells in the abdominal cavity exfoliated from the serosal surfaces of the primary gastric tumor. The study aimed to assess peritoneal cytology in the staging process of gastric cancer. Material & Methods: This Cross-sectional observational study was carried out in the Department of Surgical Oncology, National Institute of Cancer Research and Hospital, Mohakhali, Dhaka, Bangladesh for twenty-one months, starting from July 2017 to March 2019 following approval of the protocol. 42 study patients were selected based on the inclusion and exclusion criteria. The patients were diagnosed clinically, radiologically, and histopathologically. A structured case record form was used to interview and collect data. The outcome of gastric carcinoma was measured by doing peritoneal cytology. All the data were compiled and sorted properly and analyzed statistically using Statistical Package for Social Science (SPSS-22). The results were expressed as percentages and mean � SD and presented as tables and charts. Results: In the present study, the mean (盨D) age of the subjects was 66.19 (�.38). The majority (33.3%) were aged 56-65 years. Among the study subjects, 64.3% were males and 35.7% were females. 52.4%, 40.5%, and 7.1%) study subjects had BMI 18.5-24.9 kg/m2, 25-30 kg/m2 and >30 kg/m2. In this study, out of 42 patients, 61.9% were smokers and 83.3% were taking betel leaf in their habit. Here, the majority (69%) of study subjects came from the middle class. In the present study, proximal and distal stomachs were involved in study subjects. The mean � SD tumor size was 6.20 � 1.86cm. The majority of study subjects had Type 3 and Type 4 tumors and T4a and N2 stage. In this study, total gastrectomy and lower radical gastrectomy were done in the majority of the patients. The time of index surgery was 1-1.5 hours in the majority of the subjects. In the present study, 64.3% of subjects had cytology positive, 31% had cytology negative and only 4.8% of subjects had suspected cytology. Negative cytology was significantly higher in T1, T2, N0, and N1 stages and positively cytology was significantly higher in T3, T4a, and N2 stages. Conclusions: After analyzing the results of the present study, it can be concluded that the majority of subjects had cytology positive, and positive cytology was significantly higher in the T3, T4a, and N2 stages. Negative cytology was significantly higher in T1, T2, N0, and N1 stage.
Description
Keywords
Gastric carcinoma, Peritoneal cytology, Staging
Citation
Biswas Girin Chandra, Shoaib Tanvir Hasan, Prova Mahnaz Tabassum, Rahman Sonia, Rahman Mofizur, Das Shubhankar. Peritoneal Cytology in the Staging Process of Gastric Carcinoma. Annals of International Medical and Dental Research. 2024 Sep; 10(5): 64-72