Control randomized study of rehydration/rehydration with dioctahedral smectite in ambulatory Thai infants with acute diarrhea.

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dc.contributor.authorLexomboon, Uen_US
dc.contributor.authorHarikul, Sen_US
dc.contributor.authorLortholary, Oen_US
dc.date.accessioned2009-05-27T15:54:48Z
dc.date.available2009-05-27T15:54:48Z
dc.date.issued1994-03-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractThe study was performed to assess the efficiency, acceptability and safety of dioctahedral smectite (DS) associated with rehydration in ambulatory infants with acute diarrhea. Sixty-six Thai infants, aged 1-24 months were randomly divided into 2 groups. One group of 32 infants (control group) received oral or intravenous rehydration, the other group of 34 infants (DS group) received the rehydration with DS. Both groups were comparable for sex, age, weight, diet, duration of diarrhea, body temperature, nutritional and dehydration status. Bacteriological stool examination was positive in 22% in control group and 26% in DS group for Salmonella, Shigella, Campylobacter, enterotoxigenic Escherichia coli and Plesiomonas sp. Rotavirus was found in 25% of the control group and 29% of the DS group. Seventy-two hours after therapy, 34% of infants were cured in the control group compared to 71% in DS group (p < 0.01) and 5 days after the beginning of treatment, 34% still had diarrhea in the control group compared to 12% in DS group (p = 0.04). The acceptability of DS was considered to be good in 30 infants (88%). No major side effect was observed. In conclusion, DS with rehydration shortens the course of acute diarrhea in ambulatory infants and may reduce the occurrence of prolonged diarrhea. DS is well tolerated in infants with acute diarrhea.en_US
dc.description.affiliationPediatric Gastroenterology Unit, Children's Hospital, Bangkok, Thailand.en_US
dc.identifier.citationLexomboon U, Harikul S, Lortholary O. Control randomized study of rehydration/rehydration with dioctahedral smectite in ambulatory Thai infants with acute diarrhea. The Southeast Asian Journal of Tropical Medicine and Public Health. 1994 Mar; 25(1): 157-62en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/33966
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshAcute Diseaseen_US
dc.subject.meshAmbulatory Care --methodsen_US
dc.subject.meshCombined Modality Therapyen_US
dc.subject.meshDiarrhea, Infantile --microbiologyen_US
dc.subject.meshFeces --microbiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFluid Therapy --methodsen_US
dc.subject.meshGastrointestinal Agents --therapeutic useen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshSilicatesen_US
dc.subject.meshThailanden_US
dc.subject.meshTime Factorsen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleControl randomized study of rehydration/rehydration with dioctahedral smectite in ambulatory Thai infants with acute diarrhea.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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