Multicentric study on genetic causes of mental retardation in India. ICMR Collaborating Centres & Central Co-ordinating Unit.

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dc.date.accessioned1991-04-01en_US
dc.date.accessioned2009-05-27T06:44:37Z
dc.date.available1991-04-01en_US
dc.date.available2009-05-27T06:44:37Z
dc.date.issued1991-04-01en_US
dc.description.abstractA study on 1314 children with mental retardation (MR) without an obvious environmental cause was carried out at Bangalore, Bombay, Delhi and Lucknow to determine the extent and pattern of genetic causes of mental retardation in different parts of India. In all, 42.3 per cent patients had mild, 25.3 per cent moderate, 19.2 per cent severe and 13.1 per cent profound mental retardation. Among 1314 patients, the chromosomal anomalies were found in 23.7 per cent, metabolic defects in 5.0 per cent and an identificable genetic syndrome in 11.6 per cent of the patients. In the remaining 59.7 per cent patients, no known genetic cause could be identified. However, 66.5 per cent of these patients had one or more of the following conditions: (i) congenital malformation with or without neurological deficit, (ii) history of consanguinity, (iii) positive family history of mental retardation or (iv) a positive screening test but without a confirmed diagnosis of metabolic defect (suggesting that there may be additional unidentified genetic causes of mental retardation).en_US
dc.identifier.citationEditor. Multicentric study on genetic causes of mental retardation in India. ICMR Collaborating Centres & Central Co-ordinating Unit. Indian Journal of Medical Research. 1991 Apr; 94(): 161-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/17706
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAdolescenten_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshChromosome Aberrations --epidemiologyen_US
dc.subject.meshChromosome Disordersen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshInfanten_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshIntelligence Testsen_US
dc.subject.meshMaleen_US
dc.subject.meshMental Retardation --epidemiologyen_US
dc.subject.meshMetabolism, Inborn Errors --epidemiologyen_US
dc.titleMulticentric study on genetic causes of mental retardation in India. ICMR Collaborating Centres & Central Co-ordinating Unit.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeMulticenter Studyen_US
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