Angioimmunoblastic T-Cell lymphoma: A critical analysis of clinical, morphologic and immunophenotypic features.
| dc.contributor.author | Bal, Munita | |
| dc.contributor.author | Gujral, Sumeet | |
| dc.contributor.author | Gandhi, Jatin | |
| dc.contributor.author | Shet, Tanuja | |
| dc.contributor.author | Epari, Sreedhar | |
| dc.contributor.author | Subramanian, P G | |
| dc.date.accessioned | 2012-09-27T08:11:29Z | |
| dc.date.available | 2012-09-27T08:11:29Z | |
| dc.date.issued | 2010-10 | |
| dc.description.abstract | Background: Angioimmunoblastic T-cell lymphoma (AITL), a subtype of peripheral T-cell lymphoma (PTCL), is characterized by unique clinical and biological features. Its diagnosis remains a challenge as clinical presentation as well as pathologic findings are frequently misleading. Material and Methods: We retrospectively analyzed the clinical, morphological and immunophenotypic spectrum of 17 cases of histologically proven AITL. Result: The mean age was 54 years and male to female ratio was 2.4. Common clinical features included generalized lymphadenopathy (60%), hepatomegaly (70%), splenomegaly (50%), anemia (80%) and polyclonal hypergammaglobulinemia (100%). Microscopically, three architectural patterns; pattern I (6%), pattern II (41%) and pattern III (53%) were observed. Bone marrow infiltration was seen in 60% cases and 30% cases revealed plasmacytosis. Absence of follicles, polymorphous infiltrate, extra-follicular follicular dendritic cell (FDC) proliferation, high endothelial venules (HEV) prominence and neoplastic T-cells were the diagnostic features of AITL. CD10 positivity (47%), clear cells in the background (59%) admixture with large size CD20+ B-immunoblasts (35%) and bone marrow plasmacytosis (50%) were common observations. Conclusion: Awareness of various morphological and immunophenotypic complexities of AITL and distinction from reactive adenopathies and other types of lymphomas that mimic AITL is underscored in this study. | en_US |
| dc.identifier.citation | Bal Munita, Gujral Sumeet, Gandhi Jatin, Shet Tanuja, Epari Sreedhar, Subramanian P G. Angioimmunoblastic T-Cell lymphoma: A critical analysis of clinical, morphologic and immunophenotypic features. Indian Journal of Pathology & Microbiology. 2010 Oct-Dec; 53(4): 640-645. | en_US |
| dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/141778 | |
| dc.language.iso | en | en_US |
| dc.source.uri | https://www.ijpmonline.org/article.asp?issn=0377-4929;year=2010;volume=53;issue=4;spage=640;epage=645;aulast=Bal | en_US |
| dc.subject | Angioimmunoblastic T-cell lymphoma | en_US |
| dc.subject | immunohistochemistry | en_US |
| dc.subject | morphology | en_US |
| dc.title | Angioimmunoblastic T-Cell lymphoma: A critical analysis of clinical, morphologic and immunophenotypic features. | en_US |
| dc.type | Article | en_US |