Receptors for advanced glycation end products is associated with autophagy in the clear cell renal cell carcinoma

Simple item page
dc.contributor.authorGuo, Yongen_US
dc.contributor.authorZhang, Hai-Congen_US
dc.contributor.authorXue, Shengen_US
dc.contributor.authorZheng, Jun-Huaen_US
dc.date.accessioned2020-11-18T10:07:37Z
dc.date.available2020-11-18T10:07:37Z
dc.date.issued2019-04
dc.description.abstractBackground: The receptor for advanced glycation end-product (RAGE) was one of the signal transduction receptors. RAGE interacted with various signaling molecules which were involved in human disease processes including tumorigenesis. Previous reports have indicated that RAGE/high-mobility group box 1 (HMGB1) could regulate autophagy in different carcinomas. However, the functional role of RAGE/ HMGB1 in the regulation of clear cell renal cell carcinoma (ccRCC) autophagy remained unrevealed. Methods: Western blot, quantitative real-time polymerase chain reaction (qRT-PCR) and immunofluorescence were used in the present study. Results: In this study, we demonstrated that the levels of RAGE/HMGB1 and autophagic protein LC3, Beclin-1, PI3K were much higher in ccRCC samples than those of in adjacent normal tissues. RAGE and autophagic protein expression was regulated with RAGE/HMGB1 in human RCC cell lines. Conclusion: Our results implicated that RAGE and autophagy played important roles in ccRCC, and RAGE/HMGB1 might serve as a novel therapeutic target for future ccRCC treatmenten_US
dc.identifier.affiliationsDepartment of Urology, Shanghai Tenth People's Hospital of Nanjing Medical University, Nanjing; Transplantation Centre, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Chinaen_US
dc.identifier.affiliationsDepartment of Pathology, The Fifth Hospital of Shijiazhuang, Shijiazhuang, Chinaen_US
dc.identifier.affiliationsDepartment of Urology, Shanghai Tenth People's Hospital of Nanjing Medical University, Nanjing, Chinaen_US
dc.identifier.affiliationsDepartment of Urology, Shanghai General Hospital of Nanjing Medical University, Nanjing; Department of Urology, The Affiliated First People's Hospital of Shanghai Jiao Tong University, Shanghai, Chinaen_US
dc.identifier.citationGuo Yong, Zhang Hai-Cong, Xue Sheng, Zheng Jun-Hua. Receptors for advanced glycation end products is associated with autophagy in the clear cell renal cell carcinoma. Journal of Cancer Research and Therapeutics. 2019 Apr; 15(2): 317-323en_US
dc.identifier.issn0973-1482
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/213616
dc.languageenen_US
dc.publisherWolters Kluwer India Pvt. Ltd.en_US
dc.relation.issuenumber2en_US
dc.relation.volume15en_US
dc.source.urihttps://dx.doi.org//10.4103/jcrt.JCRT_180_18en_US
dc.subjectAutophagyen_US
dc.subjectclear cell renal cell carcinomaen_US
dc.subjecthigh-mobility group box 1en_US
dc.subjectreceptor for advanced glycation end-producten_US
dc.titleReceptors for advanced glycation end products is associated with autophagy in the clear cell renal cell carcinomaen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijcrt2019v15n2p317.pdf
Size:
2.41 MB
Format:
Adobe Portable Document Format
Download
Collections
Journal of Cancer Research and Therapeutics