High sensitivity C-reactive protein level in cerebrovascular accident

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dc.contributor.authorKumar, Sonal Rajeshen_US
dc.contributor.authorVidya, T. A.en_US
dc.date.accessioned2020-04-09T07:43:57Z
dc.date.available2020-04-09T07:43:57Z
dc.date.issued2020-04
dc.description.abstractBackground: Stroke is the second leading cause of death worldwide according to WHO. High sensitivity C-Reactive Protein (hs-CRP) is an acute phase reactant which is being studied extensively to delineate its role in development of stroke as well as in prognostication. This study was done to assess correlation of hs-CRP with risk factors of stroke and its association with types of stroke and prognosis.Methods: A prospective case control study of 100 patients with acute stroke along with 100 controls was conducted with informed consent. At baseline, hs-CRP levels were measured and Modified Rankin Scale (MRS) was assessed. On day 90 the Modified Rankin Scale was assessed again. Patients were divided into groups based on hs-CRP levels and MRS and the results were analysed.Results: Prevalence of stroke was more in men than women (p=0.0002). Statistically significant difference was found between mean hs-CRP levels in men (4.722±0.8982 mg/L) and women (4.133±0.9446 mg/L) (p=0.005) and between cases and controls (p=0.0003). There was no significant association with type of stroke (p=0.456). Mean total cholesterol levels between cases and controls showed statistically significant difference (p=0.0005). High MRS was significantly associated with high hs-CRP levels (p=0.003). Higher hs-CRP on day 1 correlated with higher MRS on day 90.Conclusions: hs-CRP level is increased in stroke and shows significant association with severity of stroke and prognosis.en_US
dc.identifier.affiliationsKanchipuram District, Tamil Nadu, Indiaen_US
dc.identifier.citationKumar Sonal Rajesh, Vidya T. A.. High sensitivity C-reactive protein level in cerebrovascular accident. International Journal of Advances in Medicine. 2020 Apr; 7(4): 666-672en_US
dc.identifier.issn2349-3925
dc.identifier.issn2349-3933
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/194659
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber4en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3933.ijam20201119en_US
dc.subjectHemorrhagic strokeen_US
dc.subjectHigh sensitivity C-reactive proteinen_US
dc.subjectIschemic strokeen_US
dc.subjectModified rankin scaleen_US
dc.titleHigh sensitivity C-reactive protein level in cerebrovascular accidenten_US
dc.typeJournal Articleen_US
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