Comparison of radiation and chemoradiation-induced sensorineural hearing loss in head and neck cancer patients

Aim: The purpose of this study was to assess and compare the incidence and severity of sensorineural hearing loss (SNHL) in head-and-neck patients undergoing radiotherapy (RT) and concurrent cisplatin-based chemoradiotherapy (CRT). Materials and Methods: Pure tone audiometry (PTA) was performed at 0.25–12 kHz on 35 RT and 25 CRT patients after 12-month followed up. The hearing loss was evaluated according to the Common Terminology Criteria for Adverse Events (CTCAE) criteria. Results: SNHL increased to 84% in patients who had received CRT, compared with 26% increasing in patients who had treated with RT. There was an increased risk of SNHL at all frequencies for ears received a cochlear mean dose >50 Gy in RT group, compared to those receiving cochlear mean dose >30 Gy in CRT group. SNHL was more severe at higher frequencies in both patient groups. Conclusion: Characteristic of radiation-induced SNHL is different from CRT-induced SNHL, especially in threshold radiation dose and PTA frequency.

Keywords

Concurrent chemotherapy, head, neck, pure tone audiometry, radiotherapy, sensorineural hearing loss

Citation

Mahdavi Seied Rabi, Rezaeyan Abolhasan, Nikoofar Alireza, Bakhshandeh Mohsen, Farahani Saeid, Cheraghi Susan. Comparison of radiation and chemoradiation-induced sensorineural hearing loss in head and neck cancer patients. Journal of Cancer Research and Therapeutics. 2020 Jul; 16(3): 539-545

URI

https://imsear.searo.who.int/handle/123456789/213855

Collections

Journal of Cancer Research and Therapeutics

Full item page