Clinical pharmacological studies on centpropazine--a new antidepressant compound.

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dc.contributor.authorGupta, P Pen_US
dc.contributor.authorAsthana, O Pen_US
dc.contributor.authorTangri, A Nen_US
dc.contributor.authorDhawan, B Nen_US
dc.date.accessioned1989-10-01en_US
dc.date.accessioned2009-05-27T07:17:47Z
dc.date.available1989-10-01en_US
dc.date.available2009-05-27T07:17:47Z
dc.date.issued1989-10-01en_US
dc.description.abstractSingle oral doses of 10 to 160 mg centpropazine, a new antidepressant (synthesized by CDRI, Lucknow, India) were administered to groups of 4-5 male volunteers, each dose being interspersed with placebo in a double blind, non-crossover study by random distribution. The drug was well tolerated. Drowsiness, heaviness, weakness and/or headache were reported only at doses of 120 mg and above. No adverse effect was noted in various laboratory tests, ECG or vital parameters. In a multiple dose study, volunteers received 40 or 80 mg centpropazine daily for 4 wk. Mild restlessness and insomnia were observed in some subjects receiving 80 mg dose. In this study also no effect was observed in various laboratory tests, ECG or vital parameters.en_US
dc.identifier.citationGupta PP, Asthana OP, Tangri AN, Dhawan BN. Clinical pharmacological studies on centpropazine--a new antidepressant compound. Indian Journal of Medical Research. 1989 Oct; 90(): 360-2en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/20119
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntidepressive Agents --adverse effectsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshDrug Evaluationen_US
dc.subject.meshDrug Toleranceen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPiperazinesen_US
dc.subject.meshRandom Allocationen_US
dc.titleClinical pharmacological studies on centpropazine--a new antidepressant compound.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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