Association of circulatory chemerin levels with the severity of pre-eclampsia: A systematic review and bootstrapped meta-analysis

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dc.contributor.authorVarikasuvu, SRen_US
dc.contributor.authorMadhuri, Men_US
dc.contributor.authorAli, Aen_US
dc.contributor.authorGowtham, Ken_US
dc.contributor.authorJegatheesan, Jen_US
dc.contributor.authorRanjan, Aen_US
dc.contributor.authorKumar, Aen_US
dc.contributor.authorKumari, Ben_US
dc.contributor.authorTiwari, Men_US
dc.contributor.authorSharma, S.en_US
dc.date.accessioned2025-05-09T10:45:50Z
dc.date.available2025-05-09T10:45:50Z
dc.date.issued2024-10
dc.description.abstractIntroduction: This study presents a systematic review and meta-analysis to investigate the association between circulating chemerin levels and the severity of preeclampsia (PE). Material and Methods: A thorough search was conducted across multiple databases, including PubMed/MEDLINE, SCOPUS, and the Cochrane Library, up to March 31, 2024, focusing on observational studies that compared chemerin levels in patients with severe versus mild PE. Two independent reviewers extracted mean and standard deviation (SD) values of chemerin levels from these studies. The quality and risk of bias of the included studies were assessed using the Newcastle朞ttawa Scale. Standardized mean differences (SMD) with 95% confidence intervals (CI) were calculated to evaluate the difference in chemerin levels between severe and mild PE groups. Sensitivity analyses were performed to address heterogeneity and ensure the reliability of the findings. Additionally, a bootstrapped meta-analysis with 1,000 and 10,000 simulations was conducted to further validate the results. Results: Six observational studies were included in the analysis. The findings revealed that patients with severe PE had significantly higher chemerin levels compared to those with mild PE (SMD 1.55, 95% CI 0.67�43, p < 0.0001). The bootstrapped meta-analysis supported the accuracy of these findings (SMD = 1.54, CI = 0.74�38). No publication bias was identified using Begg抯 and Egger抯 tests, and the sensitivity analysis confirmed the robustness of the results. Conclusion: This meta-analysis provides compelling evidence that chemerin levels are significantly elevated in patients with severe PE compared to those with mild PE. Further research is warranted to investigate the potential of circulating chemerin as a diagnostic marker for PE severity.en_US
dc.identifier.affiliationsDepartment of Biochemistry, All India Institute of Medical Sciences, Deoghar, Jharkhand, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, All India Institute of Medical Sciences Patna, Bihar, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, All India Institute of Medical Sciences Patna, Bihar, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, All India Institute of Medical Sciences Patna, Bihar, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, All India Institute of Medical Sciences Patna, Bihar, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, All India Institute of Medical Sciences Patna, Bihar, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, All India Institute of Medical Sciences Patna, Bihar, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, All India Institute of Medical Sciences Patna, Bihar, Indiaen_US
dc.identifier.affiliationsDepartment of Center for Advance Research, King George抯 Medical University, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, All India Institute of Medical Sciences Patna, Bihar, Indiaen_US
dc.identifier.citationVarikasuvu SR, Madhuri M, Ali A, Gowtham K, Jegatheesan J, Ranjan A, Kumar A, Kumari B, Tiwari M, Sharma S.. Association of circulatory chemerin levels with the severity of pre-eclampsia: A systematic review and bootstrapped meta-analysis. Annals of the National Academy of Medical Sciences (India). 2024 Oct; 60(4): 261-266en_US
dc.identifier.issn0379-038X
dc.identifier.issn2454-5635
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/245751
dc.languageenen_US
dc.publisherNational Academy of Medical Sciencesen_US
dc.relation.issuenumber4en_US
dc.relation.volume60en_US
dc.source.urihttps://dx.doi.org/10.25259/ANAMS_86_2024en_US
dc.subjectAdipokineen_US
dc.subjectChemerinen_US
dc.subjectPre-eclampsiaen_US
dc.subjectSystematic reviewen_US
dc.subjectMeta-analysisen_US
dc.titleAssociation of circulatory chemerin levels with the severity of pre-eclampsia: A systematic review and bootstrapped meta-analysisen_US
dc.typeJournal Articleen_US
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