Clinical characteristics & outcome of SARS-CoV-2 infected neonates presenting to paediatric emergency

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dc.contributor.authorKumar, Jogenderen_US
dc.contributor.authorKumar, Praveenen_US
dc.contributor.authorSaini, Shiv Sajanen_US
dc.contributor.authorSundaram, Venkataseshanen_US
dc.contributor.authorMukhopadhyay, Kanyaen_US
dc.contributor.authorDutta, Sourabhen_US
dc.contributor.authorPaulpandian, Raja Rajanen_US
dc.contributor.authorMittal, Piyushen_US
dc.contributor.authorDas, Swatien_US
dc.contributor.authorRameshbabu, Monishaen_US
dc.contributor.authorMandula, Phani Priyaen_US
dc.contributor.authorRanjan, Ankiten_US
dc.contributor.authorTiwari, Deepikaen_US
dc.contributor.authorTaneja, Manishen_US
dc.contributor.authorGarg, Ashoken_US
dc.contributor.authorJayashree, Murlidharanen_US
dc.contributor.authorGoyal, Kapilen_US
dc.contributor.authorSingh, Minien_US
dc.contributor.authorPuri, Goverdhan Dutten_US
dc.contributor.authorLakshmi, P.V.M.en_US
dc.contributor.authorGuru, Rashmi Ranjanen_US
dc.date.accessioned2023-08-19T04:52:08Z
dc.date.available2023-08-19T04:52:08Z
dc.date.issued2022-03
dc.description.abstractBackground & objectives: Data on neonatal COVID-19 are limited to the immediate postnatal period, with a primary focus on vertical transmission in inborn infants. This study was aimed to assess the characteristics and outcome of COVID-19 in outborn neonates. Methods: All neonates admitted to the paediatric emergency from August 1 to December 31, 2020, were included in the study. SARS-CoV-2 reverse transcription- (RT)-PCR test was done on oro/nasopharyngeal specimens obtained at admission. The clinical characteristics and outcomes of SARS-CoV-2 positive and negative neonates were compared and the diagnostic accuracy of a selective testing policy was assessed. Results: A total of 1225 neonates were admitted during the study period, of whom SARS-CoV-2 RT-PCR was performed in 969. The RT-PCR test was positive in 17 (1.8%). Mean (standard deviation) gestation and birth weight of SARS-CoV-2-infected neonates were 35.5 (3.2) wk and 2274 (695) g, respectively. Most neonates (11/17) with confirmed COVID-19 reported in the first two weeks of life. Respiratory distress (14/17) was the predominant manifestation. Five (5/17, 29.4%) SARS-CoV-2 infected neonates died. Neonates with COVID-19 were at a higher risk for all-cause mortality [odds ratio (OR): 3.1; 95% confidence interval (CI): 1.1-8.9, P=0.03]; however, mortality did not differ after adjusting for lethal malformation (OR: 2.4; 95% CI: 0.7-8.7). Sensitivity, specificity, accuracy, positive and negative likelihood ratios (95% CI) of selective testing policy for SARS-CoV-2 infection at admission was 52.9 (28.5-76.1), 83.3 (80.7-85.6), 82.8 (80.3-85.1), 3.17 (1.98-5.07), and 0.56 (0.34-0.93) per cent, respectively. Interpretation & conclusions: SARS-CoV-2 positivity rate among the outborn neonates reporting to the paediatric emergency and tested for COVID-19 was observed to be low. The selective testing policy had poor diagnostic accuracy in distinguishing COVID-19 from non-COVID illness.en_US
dc.identifier.affiliationsDepartments ofen_US
dc.identifier.affiliationsPediatricsen_US
dc.identifier.affiliationsVirologyen_US
dc.identifier.affiliationsAnaesthesia &en_US
dc.identifier.affiliationsHospital Administration &en_US
dc.identifier.affiliationsCommunity Medicine, School of Public Health, Postgraduate Institute of Medical Education & Research, Chandigarh, Indiaen_US
dc.identifier.citationKumar Jogender, Kumar Praveen, Saini Shiv Sajan, Sundaram Venkataseshan, Mukhopadhyay Kanya, Dutta Sourabh, Paulpandian Raja Rajan, Mittal Piyush, Das Swati, Rameshbabu Monisha, Mandula Phani Priya, Ranjan Ankit, Tiwari Deepika, Taneja Manish, Garg Ashok, Jayashree Murlidharan, Goyal Kapil, Singh Mini, Puri Goverdhan Dutt, Lakshmi P.V.M., Guru Rashmi Ranjan. Clinical characteristics & outcome of SARS-CoV-2 infected neonates presenting to paediatric emergency. Indian Journal of Medical Research. 2022 Jan; 155(1): 189-196en_US
dc.identifier.issn0971-5916
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/223588
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber1en_US
dc.relation.volume155en_US
dc.source.urihttps://doi.org/10.4103/ijmr.IJMR_461_21en_US
dc.subjectCOVID-19en_US
dc.subjectemergencyen_US
dc.subjectneonateen_US
dc.subjectoutbornen_US
dc.subjectSARS-CoV-2en_US
dc.subjectscreeningen_US
dc.titleClinical characteristics & outcome of SARS-CoV-2 infected neonates presenting to paediatric emergencyen_US
dc.typeJournal Articleen_US
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