Recurrent miscarriage in North Indian population: a study of association of polymorphisms in genes coding for the natural killer: cell receptor natural killer group 2, member D and its ligand MHC class I chain-related protein A

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dc.contributor.authorRawool, Anupen_US
dc.contributor.authorGupta, Satyaprakashen_US
dc.contributor.authorSingh, Bhartien_US
dc.contributor.authorPhadke, Shubha Ren_US
dc.contributor.authorSaxena, Deeptien_US
dc.contributor.authorMandal, Kausiken_US
dc.date.accessioned2020-10-16T08:06:55Z
dc.date.available2020-10-16T08:06:55Z
dc.date.issued2020-09
dc.description.abstractBackground: The objective of this present study was to investigate the possible association of natural killer group (NKG) receptors gene polymorphisms and MHC class I chain-related protein A (MICA) gene polymorphism with recurrent spontaneous abortion (RSA).Methods: Three single-nucleotide polymorphism (SNPs) in NKG2D gene (rs2255336, rs2617160 and rs2617170) and one SNP in MICA gene (MICA129) rs1051792 were assessed in 100 controls and 100 patients employing polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and agarose gel electrophoresis.Results: NKG2D (rs2617160) and MICA 129 (rs1051792) variants are associated with RSA risk in North Indian women.Conclusions: The NKG2D and MICA129 gene polymorphisms may influence the success of pregnancy in North Indian women population.en_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.citationRawool Anup, Gupta Satyaprakash, Singh Bharti, Phadke Shubha R, Saxena Deepti, Mandal Kausik. Recurrent miscarriage in North Indian population: a study of association of polymorphisms in genes coding for the natural killer: cell receptor natural killer group 2, member D and its ligand MHC class I chain-related protein A. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2020 Sep; 9(9): 3665-3671en_US
dc.identifier.issn2320-1770
dc.identifier.issn2320-1789
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/207999
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber9en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-1770.ijrcog20203837en_US
dc.subjectMICA 129 geneen_US
dc.subjectNKG2D geneen_US
dc.subjectSingle-nucleotide polymorphismen_US
dc.subjectUnexplained recurrent spontaneous abortionen_US
dc.titleRecurrent miscarriage in North Indian population: a study of association of polymorphisms in genes coding for the natural killer: cell receptor natural killer group 2, member D and its ligand MHC class I chain-related protein Aen_US
dc.typeJournal Articleen_US
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