Intravenous immunoglobulins in rhesus hemolytic disease.

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dc.contributor.authorMukhopadhyay, Kanyaen_US
dc.contributor.authorMurki, Srinivasen_US
dc.contributor.authorNarang, Anilen_US
dc.contributor.authorDutta, Sourabhen_US
dc.date.accessioned2003-09-19en_US
dc.date.accessioned2009-05-30T16:23:49Z
dc.date.available2003-09-19en_US
dc.date.available2009-05-30T16:23:49Z
dc.date.issued2003-09-19en_US
dc.description.abstractOBJECTIVE: To evaluate the role of intravenous immunoglobulins in Rh hemolytic disease of newborn. METHODS: The study included all DCT positive Rh isoimmunized babies admitted in the unit from August 2000 to February 2001. Intravenous immunoglobulins in the dose of 500 mg/kg on day 1 and day 2 of life in addition to the standard therapy. Babies who received IVIG were compared with those who did not receive IVIG for the peak bilirubin levels, duration of phototherapy, number of exchange transfusions, discharge PCV and the need for blood transfusions for late anemia till 1 months of age. RESULTS: A total of 34 babies were eligible for the study. 8 babies received IVIG and 26 babies only standard treatment. The mean maximum bilirubin levels were significantly lower in the IVIG group compared to the group who received NO IVIG (16.52 +/- 2.96 Vs 22.72 +/- 8.84, p=0.004). Five babies in the IVIG group (62.5%) and 23 babies in the NO IVIG group required exchange transfusions (88.5%, p=0.014). 12 of the 26 babies in the NO IVIG group required multiple exchange transfusions while none of the babies in IVIG group required more one exchange transfusion (p=0.03). The mean duration of phototherapy was 165 +/- 109 hours in the IVIG group as against 119 +/- 56 hours in the NO IVIG group (p=0.29). Blood transfusion for anemia was more common in the IVIG group (37.5% Vs 11.5% p=0.126) though the packed cell volumes at discharge were similar in both the groups (39.5 +/- 11 Vs 40 +/- 5.1, P=0.92). CONCLUSION: Intravenous immunoglobulins is effective in decreasing the maximum bilirubin levels and the need for repeated exchange transfusions in Rh hemolytic disease of newborn. There is however an increased need for blood transfusions for late anemia in the babies treated with IVIG.en_US
dc.description.affiliationNeonatal Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India. kanyam@satyam.net.inen_US
dc.identifier.citationMukhopadhyay K, Murki S, Narang A, Dutta S. Intravenous immunoglobulins in rhesus hemolytic disease. Indian Journal of Pediatrics. 2003 Sep; 70(9): 697-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/84528
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshErythroblastosis, Fetal --therapyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulins, Intravenous --therapeutic useen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshMaleen_US
dc.subject.meshPregnancyen_US
dc.titleIntravenous immunoglobulins in rhesus hemolytic disease.en_US
dc.typeJournal Articleen_US
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