Rapid progression of hepatitis C-induced liver failure in renal allograft recipients.

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dc.contributor.authorSeth, Avnish Kumaren_US
dc.contributor.authorAnand, Anil Chandraen_US
dc.contributor.authorGedela, Sanyasi Raoen_US
dc.contributor.authorVarma, Prem Prakashen_US
dc.contributor.authorBaliga, Krishna Venkateshen_US
dc.date.accessioned2006-05-01en_US
dc.date.accessioned2009-05-29T03:30:55Z
dc.date.available2006-05-01en_US
dc.date.available2009-05-29T03:30:55Z
dc.date.issued2006-05-01en_US
dc.description.abstractEarly mortality due to hepatitis C virus (HCV)-related liver failure in renal allograft recipients in the absence of fibrosing cholestatic hepatitis is reported infrequently. We report six renal allograft recipients with HCV infection who died of rapid progression to liver failure. Of these, 2 were detected anti-HCV positive at screening prior to kidney transplantation and 4 were diagnosed after transplantation following derangement of liver function (HCV RNA positive in all 4, anti-HCV positive in 2). Median interval between kidney transplantation and derangement of liver function was 11.8 months (range 2 to 25) and median interval between transplant and death was 27 months (range 11 to 53). Liver biopsy performed during the terminal illness in 3 patients and post-mortem liver histology in 2 patients showed chronic hepatitis with mean grade of 10.2 (range 9 to 12) and stage 2.4 (range 2 to 3). None had features of fibrosing cholestatic hepatitis.en_US
dc.description.affiliationDepartment of Gastroenterology, Army Hospital (Research & Referral), New Delhi - 110 010, India. akseth2003@yahoo.comen_US
dc.identifier.citationSeth AK, Anand AC, Gedela SR, Varma PP, Baliga KV. Rapid progression of hepatitis C-induced liver failure in renal allograft recipients. Indian Journal of Gastroenterology. 2006 May-Jun; 25(3): 155-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/65429
dc.language.isoengen_US
dc.source.urihttps://www.indianjgastro.comen_US
dc.subject.meshAdulten_US
dc.subject.meshDisease Progressionen_US
dc.subject.meshFatal Outcomeen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatitis C --complicationsen_US
dc.subject.meshHumansen_US
dc.subject.meshKidney Transplantationen_US
dc.subject.meshLiver Failure, Acute --pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshTransplantation, Homologousen_US
dc.titleRapid progression of hepatitis C-induced liver failure in renal allograft recipients.en_US
dc.typeCase Reportsen_US
dc.typeJournal Articleen_US
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