Serum Aminotransferase Level among Non- Alcoholic Fatty Liver Disease/Metabolism- Associated Steatotic Liver Disease Patients of North East India

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dc.contributor.authorBhaumik, Ren_US
dc.contributor.authorBhat, SAen_US
dc.contributor.authorBhaumik, P.en_US
dc.date.accessioned2025-05-12T08:15:08Z
dc.date.available2025-05-12T08:15:08Z
dc.date.issued2024-12
dc.description.abstractIntroduction: Non alcoholic fatty liver disease or Metabolism associated steatotic liver disease is emerging as an increasingly common liver disease worldwide, especially in association with obesity, diabetes and metabolic syndrome. Aim of the Study: This study aims at assessing serum aminotransferase enzymes: aspartate aminotransferase (AST) and alanine aminotransferase (ALT) Methods: The study was conducted in 628 patients with NAFLD diagnosed by abdominal ultrasonography. The patients were categorized into three grades based on the extent of liver fat accumulation. The patients were divided into Grade I (mild fat accumulation of 5-33%), Grade II (moderate fat accumulation of 34-66%), and Grade III (severe fat accumulation of more than 66%). Result : the work conducted showed that serum AST and ALT concentrations rose in proportion to the severity of NAFLD. In Grade I, the mean AST was 35.06 U/L and mean ALT was 39.17 U/L, while in Grade III the levels increased to 248.00 U/L of AST and 286.00 U/L of ALT, which shows severe liver inflammation. Further it was observed that, aminotransferase alterations were higher amongst male patients in all grades while the female patients’ results were relatively low. Discussion: Aminotransferase levels was normal in many grade I patients arguing the fact that normal AST and ALT levels may not effectively rule out early NAFLD. It reflects that though aminotransferase level may not increase in early NAFLD, but in later stage aminotransferase level increases invariably and requiring further noninvasive diagnostic evaluation. Conclusion: Aminotransferase level may vary in different area or community and standardization and validation is very much required . Though aminotransferase is single independent marker of inflammation of liver but confirmation by other associated non invasive marker is required.en_US
dc.identifier.affiliationsPh. D. Scholar, Department of Medical Laboratory Technology, NIMS College of Paramedical Technology, NIMS University, Jaipur, Rajasthan, Indiaen_US
dc.identifier.affiliationsProfessor, Department of Medical Biochemistry, NIMS University, Jaipur, Rajasthan, Indiaen_US
dc.identifier.affiliationsProfessor, Department of Medicine, Agartala Government Medical College, Agartala, Tripura, Indiaen_US
dc.identifier.citationBhaumik R, Bhat SA, Bhaumik P. . Serum Aminotransferase Level among Non- Alcoholic Fatty Liver Disease/Metabolism- Associated Steatotic Liver Disease Patients of North East India. International Journal of Scientific Study. 2024 Dec; 12(9): 49-54en_US
dc.identifier.issn2321-6379
dc.identifier.issn2321-595X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/246962
dc.languageenen_US
dc.publisherInternational Research Organization for Life & Health Sciencesen_US
dc.relation.issuenumber9en_US
dc.relation.volume12en_US
dc.source.urihttps://www.ijss-sn.com/uploads/2/0/1/5/20153321/08_ijss_dec_24_oa06_-_2024.pdfen_US
dc.subjectNon-Alcoholic Fatty Liver Disease (NAFLD)en_US
dc.subjectAminotransferasesen_US
dc.subjectAspartate Aminotransferase (AST)en_US
dc.subjectAlanine Aminotransferase (ALT)en_US
dc.subjectLiver Biomarkersen_US
dc.subjectMetabolism Associated Steatotic Liver Disease (MSLD)en_US
dc.titleSerum Aminotransferase Level among Non- Alcoholic Fatty Liver Disease/Metabolism- Associated Steatotic Liver Disease Patients of North East Indiaen_US
dc.typeJournal Articleen_US
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