HLA in southern Thai-Muslims.

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dc.contributor.authorChiewsilp, Pen_US
dc.contributor.authorMongkolsuk, Ten_US
dc.contributor.authorSujirachato, Ken_US
dc.contributor.authorJunpong, Sen_US
dc.contributor.authorRattanasombat, Ken_US
dc.contributor.authorUden, Cen_US
dc.date.accessioned2009-05-27T17:58:07Z
dc.date.available2009-05-27T17:58:07Z
dc.date.issued1997-09-05en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractOne hundred and two Southern Thai-Muslims (STM) from Nakhon Si Thammarat province were studied for HLA class I and II by SSP ARMS-PCR and PCR-SSO, respectively. The allele frequencies, haplotype frequencies, delta value and linkage disequilibrium between alleles were expressed. The most frequent alleles for HLA-A, HLA-B and HLA-C were A*24(02,03), A*11 (01,02), A*02(01,03,05-07,11): B*15(01,04-07,12,19,20), B*07(02-05), B*51(01-05)/B*52 (011,012); and Cw*07(01-03), Cw*04(01,02), Cw*08(01-03), respectively. The HLA class II alleles frequently found were DRB1*1202, DRB1*15021, DRB1*0701; DRB3*0301; DRB5* 0101; DQA1*0101, DQA1*0103, DQA1*0601; DQB1*0301, DQB1*0501, DQB1*0201; and DPB1*1301, DPB1*2301 and DPB1*0501. Two common HLA class I and II haplotypes with significant linkage disequilibrium were A*24 (02,03)-Cw*08 (01-03)-B*15 (01,04-07,12,19,20) -DRB1*1202 and A*33 (01,02)-Cw*0302-B*5801-DQB1*0201. The absence of B*27 and DRB1 *1401, the presence of A*2301 and high frequency of A*68 were observed in STM. Conclusion: Certain level of genetically distinction among STM, CT and NET existed. However, the genetic diversity of STM was relatively closer to CT than NET.en_US
dc.description.affiliationDepartment of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.en_US
dc.identifier.citationChiewsilp P, Mongkolsuk T, Sujirachato K, Junpong S, Rattanasombat K, Uden C. HLA in southern Thai-Muslims. Journal of the Medical Association of Thailand. 1997 Sep; 80 Suppl 1(): S30-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/38179
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAllelesen_US
dc.subject.meshChi-Square Distributionen_US
dc.subject.meshEthnic Groups --geneticsen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshHLA Antigens --classificationen_US
dc.subject.meshHaplotypesen_US
dc.subject.meshHumansen_US
dc.subject.meshIslamen_US
dc.subject.meshMalaysia --ethnologyen_US
dc.subject.meshPolymerase Chain Reaction --methodsen_US
dc.subject.meshThailanden_US
dc.titleHLA in southern Thai-Muslims.en_US
dc.typeJournal Articleen_US
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