HLA in southern Thai-Muslims.
dc.contributor.author | Chiewsilp, P | en_US |
dc.contributor.author | Mongkolsuk, T | en_US |
dc.contributor.author | Sujirachato, K | en_US |
dc.contributor.author | Junpong, S | en_US |
dc.contributor.author | Rattanasombat, K | en_US |
dc.contributor.author | Uden, C | en_US |
dc.date.accessioned | 2009-05-27T17:58:07Z | |
dc.date.available | 2009-05-27T17:58:07Z | |
dc.date.issued | 1997-09-05 | en_US |
dc.description | Chotmaihet Thangphaet. | en_US |
dc.description.abstract | One hundred and two Southern Thai-Muslims (STM) from Nakhon Si Thammarat province were studied for HLA class I and II by SSP ARMS-PCR and PCR-SSO, respectively. The allele frequencies, haplotype frequencies, delta value and linkage disequilibrium between alleles were expressed. The most frequent alleles for HLA-A, HLA-B and HLA-C were A*24(02,03), A*11 (01,02), A*02(01,03,05-07,11): B*15(01,04-07,12,19,20), B*07(02-05), B*51(01-05)/B*52 (011,012); and Cw*07(01-03), Cw*04(01,02), Cw*08(01-03), respectively. The HLA class II alleles frequently found were DRB1*1202, DRB1*15021, DRB1*0701; DRB3*0301; DRB5* 0101; DQA1*0101, DQA1*0103, DQA1*0601; DQB1*0301, DQB1*0501, DQB1*0201; and DPB1*1301, DPB1*2301 and DPB1*0501. Two common HLA class I and II haplotypes with significant linkage disequilibrium were A*24 (02,03)-Cw*08 (01-03)-B*15 (01,04-07,12,19,20) -DRB1*1202 and A*33 (01,02)-Cw*0302-B*5801-DQB1*0201. The absence of B*27 and DRB1 *1401, the presence of A*2301 and high frequency of A*68 were observed in STM. Conclusion: Certain level of genetically distinction among STM, CT and NET existed. However, the genetic diversity of STM was relatively closer to CT than NET. | en_US |
dc.description.affiliation | Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. | en_US |
dc.identifier.citation | Chiewsilp P, Mongkolsuk T, Sujirachato K, Junpong S, Rattanasombat K, Uden C. HLA in southern Thai-Muslims. Journal of the Medical Association of Thailand. 1997 Sep; 80 Suppl 1(): S30-7 | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/38179 | |
dc.language.iso | eng | en_US |
dc.source.uri | https://www.mat.or.th/journal/all.php | en_US |
dc.subject.mesh | Alleles | en_US |
dc.subject.mesh | Chi-Square Distribution | en_US |
dc.subject.mesh | Ethnic Groups --genetics | en_US |
dc.subject.mesh | Gene Frequency | en_US |
dc.subject.mesh | HLA Antigens --classification | en_US |
dc.subject.mesh | Haplotypes | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Islam | en_US |
dc.subject.mesh | Malaysia --ethnology | en_US |
dc.subject.mesh | Polymerase Chain Reaction --methods | en_US |
dc.subject.mesh | Thailand | en_US |
dc.title | HLA in southern Thai-Muslims. | en_US |
dc.type | Journal Article | en_US |
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