Effect of cisapride on corrected QT interval in neonates.

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dc.contributor.authorKhorana, Meeraen_US
dc.contributor.authorChankajorn, Woranateen_US
dc.contributor.authorKanjanapattanakul, Wiboonen_US
dc.contributor.authorKirawittaya, Tawatchaien_US
dc.contributor.authorHorpaopan, Sunthornen_US
dc.contributor.authorChotigeat, Uraiwanen_US
dc.contributor.authorSangtawesin, Warapornen_US
dc.date.accessioned2009-05-27T21:26:27Z
dc.date.available2009-05-27T21:26:27Z
dc.date.issued2003-08-01en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractOBJECTIVE: To evaluate the effect of cisapride on corrected QT (QTc) interval in neonates at the Queen Sirikit National Institute of Child Health. METHOD: A prospective study was performed to see the effects of cisapride on QTc interval in 20 neonates between 1st July 2001 and 31st January 2002. QTc interval was determined just before, 48 hours, 7 days and 15 days after the start of treatment with cisapride. QTc interval was calculated by averaging QT/square root(RR) values obtained from 5 consecutive beats in lead II of the EKG. Baseline electrolyte and calcium levels were drawn on all infants before treatment of cisapride. Drug dose ranged from 0.1-0.2 mg/kg every 6 to 8 hours. RESULTS: Twenty infants were enrolled in the survey but complete data was obtained on 18 infants only. QTc interval of > 0.45 seconds was not found in any neonate. There was no significant difference of QTc interval before and 48 hours, 7 days and 15 days after cisapride administration (p = 0.861). There were also no statistically significant effects of age at starting cisapride, weight, gestational age and dose on QTc interval (p = 0.581, 0.65, 0.8, and 0.497). There were no adverse effects such as diarrhea or jaundice during the study. CONCLUSION: Term and preterm infants using cisapride at the doses of 0.4-0.8 mg/kg/day did not develop QTc prolongation, arrhythmias or adverse effects. In the absence of risk factors, cisapride may be safe for use in neonates.en_US
dc.description.affiliationNeonatology Unit, Department of Pediatrics, Queen Sirikit National Institute of Child Health, Bangkok 10400, Thailand.en_US
dc.identifier.citationKhorana M, Chankajorn W, Kanjanapattanakul W, Kirawittaya T, Horpaopan S, Chotigeat U, Sangtawesin W. Effect of cisapride on corrected QT interval in neonates. Journal of the Medical Association of Thailand. 2003 Aug; 86 Suppl 3(): S590-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/44793
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAnalysis of Varianceen_US
dc.subject.meshCisapride --adverse effectsen_US
dc.subject.meshElectrocardiography --drug effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastroesophageal Reflux --drug therapyen_US
dc.subject.meshGastrointestinal Agents --adverse effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshIntensive Care Units, Neonatalen_US
dc.subject.meshMaleen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleEffect of cisapride on corrected QT interval in neonates.en_US
dc.typeJournal Articleen_US
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