Hepatitis E virus infection in pregnant rhesus monkeys.

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dc.contributor.authorArankalle, V Aen_US
dc.contributor.authorChadha, M Sen_US
dc.contributor.authorBanerjee, Ken_US
dc.contributor.authorSrinivasan, M Aen_US
dc.contributor.authorChobe, L Pen_US
dc.date.accessioned1993-01-01en_US
dc.date.accessioned2009-05-27T06:34:19Z
dc.date.available1993-01-01en_US
dc.date.available2009-05-27T06:34:19Z
dc.date.issued1993-01-01en_US
dc.description.abstractTen non-pregnant female monkeys and four pregnant monkeys (all Macaca mulatta) in the last third of their gestation period were infected intravenously with the stool sample of a patient with hepatitis E virus infection (immuno-electronmicroscopy positive for hepatitis E virus). Four more non-pregnant monkeys were inoculated with a lower dose (less number of virus particles by IEM) of a stool sample collected on a different day from the same patient. The average incubation period as evidenced by the rise of serum alanine transferase in the non-pregnant monkeys, was 36.4 +/- 4.9 days. The dose of the virus did not affect the incubation period. Two of the pregnant monkeys had incubation periods of 9 and 13 days respectively. They delivered healthy babies on 40th and 53rd day respectively after inoculation. At the age of 11 months, both babies were negative for anti-HEV antibodies. One monkey which delivered a healthy baby on the 2nd day after inoculation had incubation period of 36 days. The baby of this monkey was anti-HEV positive at the age of 11 months. The incubation period was 41 days in the fourth monkey which delivered a macerated foetus on the 36th day after infection. No fatality was recorded in the infected monkeys. Bile samples collected from all monkeys showed strong signals in nested polymerase chain reaction (PCR). It seems that the incubation period in pregnant monkeys was determined by the state of pregnancy.en_US
dc.description.affiliationNational Institute of Virology, Pune.en_US
dc.identifier.citationArankalle VA, Chadha MS, Banerjee K, Srinivasan MA, Chobe LP. Hepatitis E virus infection in pregnant rhesus monkeys. Indian Journal of Medical Research. 1993 Jan; 97(): 4-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/16892
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAlanine Transaminase --blooden_US
dc.subject.meshAnimalsen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshFeces --microbiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatitis E --etiologyen_US
dc.subject.meshMacaca mulattaen_US
dc.subject.meshMaleen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Complications, Infectious --etiologyen_US
dc.titleHepatitis E virus infection in pregnant rhesus monkeys.en_US
dc.typeJournal Articleen_US
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