Does cartilageER-alpha overexpression correlate with osteoarthritic chondrosenescence? Indications from Labisia pumila OA mitigation
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Date
2019-09
Journal Title
Journal ISSN
Volume Title
Publisher
Indian Academy of Sciences
Abstract
Crop productivity and yield are adversely affected by abiotic and biotic stresses. Therefore, finding out the genesresponsible for stress tolerance is a significant stride towards crop improvement. A gene co-expression network is apowerful tool to detect the most connected genes during heavy metal (HM) stress in plants. The most connected genes maybe responsible for HM tolerance by altering the different metabolic pathways during the biotic and abiotic stress. In thesame line we have performed the GSE86807 microarray analysis of chickpea during exposure to chromium, cadmium andarsenic and analyzed the data. Common differentially expressed genes (DEGs) during exposure to chromium, cadmium andarsenic were identified and a co-expression network study was carried out. Hub and bottleneck genes were explored on thebasis of degree and betweenness centrality, respectively. A gene set enrichment analysis study revealed that genes likehaloacid dehydrogenase, cinnamoyl CoA reductase, F-box protein, GDSL esterase lipase, cellulose synthase, b-glucosidase13 and isoflavone hydroxylase are significantly enriched and regulate the different pathways like riboflavin metabolism,phenyl propanoid biosynthesis, amino acid biosynthesis, isoflavonoid biosynthesis and indole alkaloid biosynthesis.
Description
Keywords
ER-alpha, diclofenac, Labisia pumila, osteoarthritis, subchondral bone
Citation
Madzuki Iffah Nadhira, Lau Seng Fong, Shalan Nor Aijratul Asikin Mohamad, Ishak Nur Iliyani Mohd, Mohamed Suhaila. Does cartilageER-alpha overexpression correlate with osteoarthritic chondrosenescence? Indications from Labisia pumila OA mitigation. Journal of Biosciences. 2019 Sep; 44(4): 1-11