Effects of prednisolone and dexamethasone on (pro)insulin biosynthesis and insulin release by rat islets of Langerhans.

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dc.contributor.authorChandrasekar, Ben_US
dc.contributor.authorMukherjee, S Ken_US
dc.date.accessioned1989-08-01en_US
dc.date.accessioned2009-05-27T09:46:07Z
dc.date.available1989-08-01en_US
dc.date.available2009-05-27T09:46:07Z
dc.date.issued1989-08-01en_US
dc.description.abstractAdministration of either prednisolone or dexamethasone (10 mg/kg body wt/day/oral) to rats for 21 days resulted in inhibition of (pro)insulin biosynthesis and immunoreactive insulin release by isolated islets. A gradual reversal of prednisolone's effect was obtained after exposing islets to increasing glucose concentrations but glucose challenges failed to influence dexamethasone's effect.en_US
dc.identifier.citationChandrasekar B, Mukherjee SK. Effects of prednisolone and dexamethasone on (pro)insulin biosynthesis and insulin release by rat islets of Langerhans. Indian Journal of Biochemistry & Biophysics. 1989 Aug; 26(4): 278-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/28502
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDexamethasone --pharmacologyen_US
dc.subject.meshInsulin --secretionen_US
dc.subject.meshIslets of Langerhans --drug effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshPrednisolone --pharmacologyen_US
dc.subject.meshProinsulin --biosynthesisen_US
dc.subject.meshRatsen_US
dc.titleEffects of prednisolone and dexamethasone on (pro)insulin biosynthesis and insulin release by rat islets of Langerhans.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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