Clinicopathologic significance of fascin, extracellular matrix metalloproteinase inducer, and ezrin expressions in colorectal adenocarcinoma.

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dc.contributor.authorJung, Eun-Joo
dc.contributor.authorLee, Ju-Han
dc.contributor.authorMin, Byung-Wook
dc.contributor.authorKim, Young-Sik
dc.contributor.authorChoi, Jong Sang
dc.date.accessioned2012-10-01T10:47:14Z
dc.date.available2012-10-01T10:47:14Z
dc.date.issued2011-01
dc.description.abstractBackground: The over expression of fascin, extracellular matrix metalloproteinase inducer (EMMPRIN), and ezrin proteins has been associated with poor prognosis in various carcinomas and sarcomas. However, very few studies have reported the relationship between the expression of fascin, EMMPRIN, and ezrin proteins and the clinico-pathologic parameters of colorectal carcinomas. Aims: The aim was to investigate the relationship between fascin, EMMPRIN, and ezrin proteins in colorectal adenocarcinomas and their correlation with clinico-pathologic parameters. Settings and Design: The expression of fascin, EMMPRIN, and ezrin proteins was studied in 210 colorectal adenocarcinoma patients through immunohistochemical staining. Materials and Methods: Immunohistochemical staining by the avidin-biotin peroxidase method was done. The scoring of each protein expression was done and divided into three groups (negative, low-, and high-expression groups). Statistical Analysis: A chi-square test, and Kendall's tau-b correlation test were used for comparing. Survival analysis was performed using the Kaplan-Meier method with log-rank tests and the Cox proportional hazard model. Results: The percentages of the high-expression group of fascin, EMMPRIN, and ezrin proteins in colorectal adenocarcinomas were 24%, 73%, and 62%, respectively. Weak positive correlations were observed among these protein expressions. An increased expression of the fascin protein was significantly associated with advanced tumor depth and shorter survival times, and a high expression of fascin protein was an independent prognostic factor in univariate and multivariate survival analyses. EMMPRIN and ezrin protein expressions were not associated with the clinico-pathologic parameters. Conclusions: The high expression of fascin protein may be an unfavorable prognostic marker for individual colorectal cancer patients.en_US
dc.identifier.citationJung Eun-Joo, Lee Ju-Han, Min Byung-Wook, Kim Young-Sik, Choi Jong Sang. Clinicopathologic significance of fascin, extracellular matrix metalloproteinase inducer, and ezrin expressions in colorectal adenocarcinoma. Indian Journal of Pathology & Microbiology. 2011 Jan-Mar 54(1): 32-36.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/141911
dc.language.isoenen_US
dc.source.urihttps://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=1;spage=32;epage=36;aulast=Jungen_US
dc.subjectColorectal canceren_US
dc.subjectextracellular matrix metalloproteinase induceren_US
dc.subjectezrinen_US
dc.subjectfascinen_US
dc.subjectprognosisen_US
dc.subject.meshAdenocarcinoma --diagnosis
dc.subject.meshAdenocarcinoma --pathology
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshAntigens, CD147 --analysis
dc.subject.meshBiological Markers --analysis
dc.subject.meshCarrier Proteins --analysis
dc.subject.meshColorectal Neoplasms --diagnosis
dc.subject.meshColorectal Neoplasms --pathology
dc.subject.meshCytoskeletal Proteins --analysis
dc.subject.meshFemale
dc.subject.meshGene Expression Profiling
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry
dc.subject.meshMale
dc.subject.meshMicrofilament Proteins --analysis
dc.subject.meshMiddle Aged
dc.subject.meshPrognosis
dc.subject.meshYoung Adult
dc.titleClinicopathologic significance of fascin, extracellular matrix metalloproteinase inducer, and ezrin expressions in colorectal adenocarcinoma.en_US
dc.typeArticleen_US
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