Outcome of recurrent and persistent disease of malignant ovarian germ cell tumor: a retrospective analysis at King Chulalongkorn Memorial Hospital.

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dc.contributor.authorLertkhachonsuk, Ruangsaken_US
dc.contributor.authorManchana, Tarineeen_US
dc.contributor.authorTermrungruanglert, Wichaien_US
dc.contributor.authorVasuratna, Apichaien_US
dc.contributor.authorSittisomwong, Tulen_US
dc.contributor.authorWorasethsin, Pongkasemen_US
dc.contributor.authorSirisabya, Nakarinen_US
dc.contributor.authorKhemapech, Niponen_US
dc.contributor.authorTresukosol, Damrongen_US
dc.date.accessioned2009-05-27T21:53:51Z
dc.date.available2009-05-27T21:53:51Z
dc.date.issued2006-02-04en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractMalignant ovarian germ cell tumor has one of the most successful treatment outcomes in gynecological malignancy. More than 80% of the patients can be cured from this rare type of tumor However, patients with recurrent and persistent disease after primary treatment are still the problem of management. The present study has reviewed the treatment outcome of this cancer in King Chulalongkorn Memorial Hospital during the 12 years periodfrom 1993 to 2004. The overall cases of malignant ovarian germ cell tumor were 71 cases, 8 cases had recurrent disease after primary treatment and all cases received platinum-based chemotherapy for the salvage treatment. All patients in this group received long-term survival with median survival time of 87 months. In patients with persistent disease, 10 cases that resisted to first line adjuvant chemotherapy. Cisplatin and Etoposide regimen was applied as second line treatment, but none of these patients received long term response. The survival outcomes in these 2 groups are significantly different. The overall survival from the treatment of malignant ovarian germ cell tumor in King Chulalongkorn Memorial Hospital was 85.1%. In conclusion, the outcome of treatment in patients with recurrent disease after non-platinum chemotherapy is excellent. Salvage therapy in this group should contain platinum-based regimen. Patients whose disease persisted after platinum-containing regimen had a poor survival outcome.en_US
dc.description.affiliationGynecologic Oncology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.en_US
dc.identifier.citationLertkhachonsuk R, Manchana T, Termrungruanglert W, Vasuratna A, Sittisomwong T, Worasethsin P, Sirisabya N, Khemapech N, Tresukosol D. Outcome of recurrent and persistent disease of malignant ovarian germ cell tumor: a retrospective analysis at King Chulalongkorn Memorial Hospital. Journal of the Medical Association of Thailand. 2006 Feb; 89(2): 138-44en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/45593
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAge Factorsen_US
dc.subject.meshBiopsy, Needleen_US
dc.subject.meshChemotherapy, Adjuvanten_US
dc.subject.meshChilden_US
dc.subject.meshCombined Modality Therapyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHospitals, Universityen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasm Recurrence, Local --mortalityen_US
dc.subject.meshNeoplasm Stagingen_US
dc.subject.meshNeoplasms, Germ Cell and Embryonal --mortalityen_US
dc.subject.meshOvarian Neoplasms --mortalityen_US
dc.subject.meshOvariectomy --methodsen_US
dc.subject.meshProbabilityen_US
dc.subject.meshPrognosisen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshRisk Assessmenten_US
dc.subject.meshSurvival Analysisen_US
dc.subject.meshThailanden_US
dc.titleOutcome of recurrent and persistent disease of malignant ovarian germ cell tumor: a retrospective analysis at King Chulalongkorn Memorial Hospital.en_US
dc.typeJournal Articleen_US
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