Diagnostic value of Adenosine Deaminase (ADA) Activity inTubercular Serositis.
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Date
2006-04
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Abstract
Background: Adenosine deaminase has been proposed to be a useful surrogate marker for tuberculosis in pleural,
pericardial and peritoneal fluids. Studies have confirmed high sensitivity and specificity of Adenosine deaminase for
early diagnosis of extra pulmonary tuberculosis.
Aim: To assess the diagnostic level of ADA in tubercular serosal effusion and to determine its sensitivity and
specificity.
Methods: The study was carried out on 120 patients suffering from serosal effusion (50 pleural, 50 peritoneal, and
20 cases of pericardial effusion) . Detailed clinical history, physical examination and routine and relevant investigation
of all patients including ADA estimation by GALANTI AND GIUSTI method was done.
Results: ADA Level in tuberculous pleural effusion ranged from 45-160 U/L with a mean level of 100U/L and
sensitivity and specificity of 100% (p<0.001, highly significant). ADA level in tuberculous peritoneal effusion
ranged from 35-135 U/L with a mean level of 92U/L and sensitivity and specificity of 100% and 95% respectively
(p<0.001, highly significant). ADA level in tubercular pericardial effusion ranged from 63-117 U/L with a mean
level of 90U/L and sensitivity and specificity of 100% and 83.3% respectively (p<0.005, very significant).In toto
serosal fluid ADA level estimation offers high degree of sensitivity and specificity of about 100% and 94.6%
respectively,
Conclusion: ADA was found positive with a mean value of 100U/L, 92U/L and 90 U/L in tubercular pleural,
peritoneal and pericardial effusion respectively with overall 100% sensitivity and 94.6% specificity and cutoff
value of 40 U/L.
Description
Keywords
Tubercular Serositis, Adenosine Deaminase
Citation
Mathur P C, Tiwari K K, Trikha Sushma, Tiwari Dharmendra. Diagnostic value of Adenosine Deaminase (ADA) Activity inTubercular Serositis. Indian Journal of Tuberculosis. 2006 Apr; 53(2): 92-95.