Inflammation and MMPs in alcohol-induced liver diseases and protective action of antioxidants.

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dc.contributor.authorBanerjee, Pamela
dc.contributor.authorJana, Sayantan
dc.contributor.authorChakraborty, Somsuta
dc.contributor.authorSwarnakar, Snehasikta
dc.date.accessioned2014-02-04T07:57:15Z
dc.date.available2014-02-04T07:57:15Z
dc.date.issued2013-10
dc.description.abstractThe consumption of alcohol causes several liver-associated diseases all over the world. Alcoholic liver diseases (ALD) include hepatic inflammation, fatty liver, hepatitis, liver cirrhosis and fibrosis and finally hepatocellular carcinoma. Although the cellular, metabolic and biochemical mechanisms for these diseases are quite explicable, the roles of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) are still under investigation. The present review describes the roles and regulation of MMPs and TIMPs in different ALDs along with the involvement of other pathways. This review also summarizes the present knowledge on clinical and experimental trials with different antioxidants that help against alcohol associated liver diseases.en_US
dc.identifier.citationBanerjee Pamela, Jana Sayantan, Chakraborty Somsuta, Swarnakar Snehasikta. Inflammation and MMPs in alcohol-induced liver diseases and protective action of antioxidants. Indian Journal of Biochemistry & Biophysics. 2013 Oct; 50(5): 377-386.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/150247
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/22655en_US
dc.subjectAlcoholic liver diseasesen_US
dc.subjectAntioxidantsen_US
dc.subjectMatrix metalloproteinaseen_US
dc.subjectTissue inhibitor of MMPsen_US
dc.subject.meshAntioxidants --pharmacology
dc.subject.meshCytoprotection --drug effects
dc.subject.meshInflammation --complications
dc.subject.meshLiver Diseases, Alcoholic --complications
dc.subject.meshLiver Diseases, Alcoholic --enzymology
dc.subject.meshLiver Diseases, Alcoholic --pathology
dc.subject.meshLiver Diseases, Alcoholic --prevention & control
dc.subject.meshMatrix Metalloproteinases --metabolism
dc.titleInflammation and MMPs in alcohol-induced liver diseases and protective action of antioxidants.en_US
dc.typeArticleen_US
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