Hypolipidemic activity of Hibiscus rosa sinensis root in rats.

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dc.contributor.authorKumar, Vishnu
dc.contributor.authorSingh, Pradyumn
dc.contributor.authorChander, Ramesh
dc.contributor.authorMahdi, Farzana
dc.contributor.authorSingh, Sushma
dc.contributor.authorSingh, Ranjana
dc.contributor.authorKhanna, Ashok Kumar
dc.contributor.authorSaxena, Jitendra Kumar
dc.contributor.authorMahdi, Abbas Ali
dc.contributor.authorSingh, Vinod Kumar
dc.contributor.authorSingh, Raj Kumar
dc.date.accessioned2011-11-11T09:24:11Z
dc.date.available2011-11-11T09:24:11Z
dc.date.issued2009-12
dc.description.abstractThe hypolipidemic activity of Hibiscus rosa sinensis (family Malvaceae) root extract was studied on triton and cholesterol-rich high fat diet (HFD) induced models of hyperlipidemia in rats. In triton WR-1339-induced hyperlipidemia, feeding with root extract (500 mg/kg body wt/day p.o.) exerted lipid-lowering effect, as assessed by reversal of plasma levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG) and reactivation of post-heparin lipolytic activity (PHLA) of plasma. The other model was fed with cholesterol-rich HFD and root extract (500 mg/kg body wt/ day p.o.) simultaneously for 30 days. This also caused lowering of lipid levels in plasma and liver homogenate and reactivation of plasma PHLA and hepatic total lipoprotein lipase activity. The hypolipidemic activity of Hibiscus rosa sinensis root was compared with a standard drug guggulipid (200 mg/kg body wt/day p.o.), a known lipid- lowering agent in both models. Histopathological findings in rat liver supported the protective role of H. rosa sinensis root extract in preventing cholesterol-rich HFD-induced hepatic steatosis.en_US
dc.identifier.citationKumar Vishnu, Singh Pradyumn, Chander Ramesh, Mahdi Farzana, Singh Sushma, Singh Ranjana, Khanna Ashok Kumar, Saxena Jitendra Kumar, Mahdi Abbas Ali, Singh Vinod Kumar, Singh Raj Kumar. Hypolipidemic activity of Hibiscus rosa sinensis root in rats. Indian Journal of Biochemistry & Biophysics. 2009 Dec; 46(6): 507-510.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/135235
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/7255/1/IJBB%2046%286%29%20507-510.pdfen_US
dc.subjectHibiscus rosa sinensisen_US
dc.subjectTritonen_US
dc.subjectCholesterol hyperlipidemiaen_US
dc.subjectHypolipidemic agenten_US
dc.subjectPost-heparin lipolytic activityen_US
dc.subjectHepatic lipoprotein lipase activityen_US
dc.subjectHepatic steatosisen_US
dc.subject.meshAnimals
dc.subject.meshCholesterol --metabolism
dc.subject.meshDietary Fats --adverse effects
dc.subject.meshHibiscus --chemistry
dc.subject.meshHyperlipidemias --chemically induced
dc.subject.meshHyperlipidemias --metabolism
dc.subject.meshHyperlipidemias --pathology
dc.subject.meshHypolipidemic Agents --pharmacology
dc.subject.meshLiver --drug effects
dc.subject.meshLiver --pathology
dc.subject.meshMale
dc.subject.meshPhytotherapy
dc.subject.meshPlant Extracts --pharmacology
dc.subject.meshPlant Roots --chemistry
dc.subject.meshPolyethylene Glycols --pharmacology
dc.titleHypolipidemic activity of Hibiscus rosa sinensis root in rats.en_US
dc.typeArticleen_US
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