Epstein-Barr virus serology in the diagnosis of nasopharyngeal carcinoma.

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dc.contributor.authorWong, Madeline M Fen_US
dc.contributor.authorLye, Munn-Sannen_US
dc.contributor.authorCheng, Hwee-Mingen_US
dc.contributor.authorSam, Choon-Kooken_US
dc.date.accessioned2009-05-27T17:15:27Z
dc.date.available2009-05-27T17:15:27Z
dc.date.issued2005-03-07en_US
dc.descriptionPublished by the Allergy and Immunology Society of Thailand.en_US
dc.description.abstractThe antibody levels to viral capsid antigen (VCA) and early antigen (EA) of Epstein-Barr virus (EBV) in 164 nasopharyngeal carcinoma (NPC) patients from Sarawak, East Malaysia were significantly higher than those in 147 sex, age and ethnically matched healthy controls. As diagnostic markers of NPC, IgG/VCA at reciprocal titers > or =160 was the most sensitive (89%, with 98% specificity), while IgA/EA at > or =5 was the most specific (100%) but the least sensitive (75%). The sensitivity and specificity of IgA/VCA at reciprocal titers > or =10 were 84% and 97%. IgA/VCA has an advantage over IgG/VCA despite the slightly lower sensitivity due to its consistently more distinct fluorescence reaction. The sensitivity and specificity can be marginally improved by a combination of two tests.en_US
dc.description.affiliationInstitute of Postgraduate Studies, University of Malaya, 50603 Kuala Lumpur, Malaysia.en_US
dc.identifier.citationWong MM, Lye MS, Cheng HM, Sam CK. Epstein-Barr virus serology in the diagnosis of nasopharyngeal carcinoma. Asian Pacific Journal of Allergy and Immunology. 2005 Mar; 23(1): 65-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/36795
dc.language.isoengen_US
dc.subject.meshAntibodies, Viral --blooden_US
dc.subject.meshAntigens, Viral --immunologyen_US
dc.subject.meshCapsid Proteins --immunologyen_US
dc.subject.meshCarcinoma --diagnosisen_US
dc.subject.meshFluorescent Antibody Technique, Indirecten_US
dc.subject.meshHerpesvirus 4, Human --immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin A --blooden_US
dc.subject.meshImmunoglobulin G --blooden_US
dc.subject.meshMalaysia --epidemiologyen_US
dc.subject.meshNasopharyngeal Neoplasms --diagnosisen_US
dc.subject.meshSensitivity and Specificityen_US
dc.subject.meshTumor Markers, Biological --blooden_US
dc.titleEpstein-Barr virus serology in the diagnosis of nasopharyngeal carcinoma.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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