Effect of Michelia champaca Linn on pylorous ligated rats.
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Date
2011-04
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Abstract
Michelia champaca Linn(Magnoliaceae) is used in folk medicine for the treatment of ulcers and
it is main species of Michelia used for the treatment of gastric ulcers. However, there have been
no reports regarding the anti-ulcer activity of Michelia champaca Linn extracts. Therefore, this
study was carried out to evaluate the anti-ulcerogenic property of the alcoholic and aqueous
extracts of leaves and flowers of Michelia champaca Linn. The anti-ulcer assays were performed
using nonsteroidal anti-inflammatory drug (NSAID)- aspirin induced ulcer. The effects of the
extracts on gastric content volume, pH, total acidity, ulcer index and stomach using the pylorus
ligated model were evaluated at a dose of 300mg/kg. In the aspirin induced ulcer model, it was
observed that the treatment with Michelia champaca Linn extracts significantly reduced the
gastric juice, total acidity, ulcer index and elevation in gastric pH. The results were comparable
with the positive control cimetidine 50mg/kg. Further the results were confirmed using
histopathological studies of the stomach. These results showed the anti-ulcerogenic property of
Michelia champaca Linn extracts. The maximum efficacy was shown by the flower aqueous
extract followed by leaf alcoholic, flower alcoholic and leaf aqueous extracts.
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Keywords
Michelia Champaca Linn, Pylorous Ligation, Antiulcer
Citation
Mullaicharam A R, Kumar M Surendra. Effect of Michelia champaca Linn on pylorous ligated rats. Journal of Applied Pharmaceutical Science. 2011 Apr; 1(2): 60-64.