Newborn screening for congenital adrenal hyperplasia in Sapporo City: sixteen years experience.

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dc.contributor.authorMikami, Aen_US
dc.contributor.authorFukushi, Men_US
dc.contributor.authorOda, Hen_US
dc.contributor.authorFujita, Ken_US
dc.contributor.authorFujieda, Ken_US
dc.date.accessioned2009-05-27T15:57:32Z
dc.date.available2009-05-27T15:57:32Z
dc.date.issued1999-12-13en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractA screening program for congenital adrenal hyperplasia (CAH) in Sapporo began in 1982, 7 years prior to the introduction of the national program. Since its inception, testing has involved the detection of 17-hydroxyprogesterone (17-OHP) in dried blood samples, using ELISA. Up to the end of March 1998, of 298,731 newborn screened, second samples were requested in 1,723 cases (0.6%). This number included 789 newborns who weighed less than 2,000 gm at birth. A total of 14 cases were diagnosed with 21-hydroxylase deficiency (21-OHD). "Salt-wasting type (SW)" outnumbered "simple virilizing type (SV)" by 11:3. The ratio of male to female was a converse. but unrelated, 3:11. Our study from 1982-1997 revealed that the incidence of 21-OHD in Sapporo City was 1:21.338, markedly similar to the worldwide incidence of 1:15,000. In order to improve the program, other type of analysis are also currently in use and under evaluation. These include highly sensitive HPLC analysis for 17-OHP and molecular analysis to identify some mutations associated with the 21-OHD gene (CYP21). These methodologies are very useful for the confirmation of information acquired from dried blood specimens.en_US
dc.description.affiliationSapporo City Institute of Public Health, Sapporo, Japan.en_US
dc.identifier.citationMikami A, Fukushi M, Oda H, Fujita K, Fujieda K. Newborn screening for congenital adrenal hyperplasia in Sapporo City: sixteen years experience. The Southeast Asian Journal of Tropical Medicine and Public Health. 1999 ; 30 Suppl 2(): 100-2en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/34076
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.mesh17-alpha-Hydroxyprogesterone --blooden_US
dc.subject.meshAdrenal Hyperplasia, Congenital --diagnosisen_US
dc.subject.meshChromatography, High Pressure Liquiden_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshJapan --epidemiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshNeonatal Screeningen_US
dc.titleNewborn screening for congenital adrenal hyperplasia in Sapporo City: sixteen years experience.en_US
dc.typeJournal Articleen_US
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