Combination of interferon alfa-2b and ribavirin in relapsed or nonresponding chronic hepatitis C patients following interferon therapy.

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dc.contributor.authorLesmana, Laurentius A
dc.contributor.authorBudihusodo, Unggul
dc.contributor.authorAkbar, Nurul
dc.contributor.authorSulaiman, Ali
dc.contributor.authorNoer, Sjaifoellah
dc.contributor.authorKristanti, Inge Ade
dc.contributor.authorSetiabudy, Rianto
dc.date.accessioned2013-11-15T05:52:09Z
dc.date.available2013-11-15T05:52:09Z
dc.date.issued2001-10
dc.description.abstractTwenty six patients (pts) with chronic hepatitis C (CHC) who reLapsed or non-responded following.interferon (IFN) therapy were given lFN alfa-2b 3 MIU three times a week for 48 weeks in combination with Ribavirin 800-1000 mg daily 2I (80,8%) of the 26.pts completed the study consisted of 12 relapsers and 9 non-responders. Five pts dropped out due to drug adverse events in three pts and non-drug related reason in the other two. In the relapsed group complete response, relapse and sustained response rates were obtained in 9/12(75%), 2/2 (16,5%) and 7/12(58,3%) pts respectively. In the non- responding group, these figures were 3/9 (33,3%), 1/9(I1,1%), and 2/9(22,2%) pts, respectively. The most frequent adverse event was flu-like syndrome, which was found in 18 pts (85,7%). Combination therapy of IFN alfa-2b and ribavirin may induce sustained virological response in relapsed and non-responding CHC patients. This combination therapy is more effective for relapsers compared to for non-responders.en_US
dc.identifier.citationLesmana Laurentius A, Budihusodo Unggul, Akbar Nurul, Sulaiman Ali, Noer Sjaifoellah, Kristanti Inge Ade, Setiabudy Rianto. Combination of interferon alfa-2b and ribavirin in relapsed or nonresponding chronic hepatitis C patients following interferon therapy. Medical Journal of Indonesia. 2001 Oct; 10(4): 214-217.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/149339
dc.language.isoenen_US
dc.source.urihttps://mji.ui.ac.id/journal/index.php/mji/article/view/37en_US
dc.subjectChronic hepatitis Cen_US
dc.subjectcombination therapyen_US
dc.subjectinterferonen_US
dc.subjectribavirinen_US
dc.subject.meshHepatitis C, Chronicen_US
dc.subject.meshInterferonsen_US
dc.subject.meshRibavirinen_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.titleCombination of interferon alfa-2b and ribavirin in relapsed or nonresponding chronic hepatitis C patients following interferon therapy.en_US
dc.typeArticleen_US
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