Event related potential (ERP) P300 after 6 months residence at 4115 meter.

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dc.contributor.authorThakur, Lalan
dc.contributor.authorRay, Koushik
dc.contributor.authorAnand, J P
dc.contributor.authorPanjwani, Usha
dc.date.accessioned2011-12-07T10:22:43Z
dc.date.available2011-12-07T10:22:43Z
dc.date.issued2011-07
dc.description.abstractBackground & objectives: The P300 wave is an event related potential (ERP) elicited by infrequent, task-relevant stimuli and appeared at about 300 ms, represents higher cognitive function of information processing, working memory or stimulus categorization. Hypobaric hypoxia deteriorates the cognitive function during the short term stay (days to few weeks) at high altitude. The present study was carried out to evaluate the P300 responses during long duration stay (1 month and 6 months) at high altitude (HA, 4115 m) in a sample of Indian lowlanders. Methods: The study was carried out on 18 healthy male volunteers at sea level (SL). The volunteers were stage inducted to 4115 m altitude in the Eastern Himalayas. The P300 was recorded after 1 and 6 months of their stay at HA. Results: The latencies of peaks N100, P200 and N200 waves did not show any significant changes after 1 and 6 months of stay at HA as compared to SL. The P300 latency was significantly delayed after 1 month and further delayed after 6 month of residence at 4115 m. The P200 and P300 amplitudes did not show any changes. Interpretation & conclusions: The increase in P300 latency indicated that long duration of stay at high altitude slows the stimulus evaluation processes. The observations suggest that hypoxia causes slowing of the signal processing at HA. The magnitude of the effects of hypobaric hypoxia may be dependent upon the duration of residence at high altitude.en_US
dc.identifier.citationThakur Lalan, Ray Koushik, Anand J P, Panjwani Usha. Event related potential (ERP) P300 after 6 months residence at 4115 meter. Indian Journal of Medical Research. 2011 Jul; 134(1): 113-117.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/135737
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171904/en_US
dc.subjectCognitionen_US
dc.subjectERPen_US
dc.subjecthigh altitudeen_US
dc.subjecthypobaric hypoxiaen_US
dc.subjectP300en_US
dc.subject.meshAdult
dc.subject.meshAltitude
dc.subject.meshAnaerobiosis --physiology
dc.subject.meshEvent-Related Potentials, P300
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMild Cognitive Impairment --pathology
dc.subject.meshReaction Time
dc.subject.meshTime Factors
dc.subject.meshYoung Adult
dc.titleEvent related potential (ERP) P300 after 6 months residence at 4115 meter.en_US
dc.typeArticleen_US
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