Risk of progression to overt hypothyroidism in Indian patients with subclinical hypothyroidism: a prospective observational study

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dc.contributor.authorSingh, Shailendra Kumaren_US
dc.contributor.authorSingh, Rinaen_US
dc.contributor.authorSingh, Santosh Kumaren_US
dc.contributor.authorIquebal, Mir Asifen_US
dc.contributor.authorJaiswal, Sarikaen_US
dc.contributor.authorRai, Pradeep Kumaren_US
dc.date.accessioned2023-08-28T06:36:34Z
dc.date.available2023-08-28T06:36:34Z
dc.date.issued2022-12
dc.description.abstractBackground:Subclinical hypothyroidism (SCH) is a common endocrine disorder but spontaneous course of SCH in India is lacking. The aim of the study is to determine the spontaneous course of SCH and to identify the risk factors, which enhances the occurrence of overt hypothyroidism (OH).Method: This is a real world prospective observational study. 58 SCH were followed up six monthly for one year to determine the course of SCH.Results: After one year of follow up 11 (18.97%) patients progressed to OH. 37 (63.79%) remained in subclinical hypothyroid category. In 10 (17.29%) patients TSH (thyrotropin) normalized. Rate of progression (odds ratio: 4.58; 95% CI: 1.14, 18.28) was significantly more in anti-thyroid peroxidase (TPO) positive group as compared to anti-TPO negative group. Conclusions: This first data from India clearly shows that SCH has a variable course. Rate of progression to OH is high (18.97%) in Indian SCH patients. In a cohort of 58 patients followed for one year only the presence of anti-TPO antibody waspredictive of OH. The initial risk stratification can identify patients with SCH at greatest risk for progression to OH in which treatment is mandatory.en_US
dc.identifier.affiliationsDepartment of Endocrinology, Endocrine Clinic,Varanasi, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Endocrinology, Endocrine Center,Patna,Bihar, Indiaen_US
dc.identifier.affiliationsDivision of Agricultural Bioinformatics, ICAR-IASRI, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Nephrology, Opal Hospital, Varanasi, Uttar Pradesh, Indiaen_US
dc.identifier.citationSingh Shailendra Kumar, Singh Rina, Singh Santosh Kumar, Iquebal Mir Asif, Jaiswal Sarika, Rai Pradeep Kumar. Risk of progression to overt hypothyroidism in Indian patients with subclinical hypothyroidism: a prospective observational study. International Journal of Advances in Medicine. 2022 Dec; 9(12): 1183-1187en_US
dc.identifier.issn2349-3933
dc.identifier.issn2349-3925
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/225927
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber12en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3933.ijam20223019en_US
dc.subjectSCHen_US
dc.subjectOHen_US
dc.subjectProgressionen_US
dc.subjectAnti-TPO antibodyen_US
dc.titleRisk of progression to overt hypothyroidism in Indian patients with subclinical hypothyroidism: a prospective observational studyen_US
dc.typeJournal Articleen_US
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