Expression of Cyclin D1 in normal and hyperplastic endometrium

Simple item page
dc.contributor.authorKundu, Parveen R.en_US
dc.contributor.authorSindhu, Anjalien_US
dc.contributor.authorKaur, Swaranen_US
dc.contributor.authorKulhria, Amritaen_US
dc.contributor.authorHooda, Ritikaen_US
dc.date.accessioned2020-10-16T07:59:55Z
dc.date.available2020-10-16T07:59:55Z
dc.date.issued2019-11
dc.description.abstractBackground: Endometrial hyperplasia is characterised by increased gland to stroma ratio with varying degree of atypia. Cyclin D1 is a protein playing important role during the G1→S phase transition in the cell cycle. The present study evaluated the expression of Cyclin D1 in normal and hyperplastic endometrium.Methods: A cross sectional study was conducted over a period of 1 year. We evaluated and compared the expression of Cyclin D1 in 56 endometrial samples including 24 cases of simple hyperplasia, 12 cases of complex hyperplasia and 10 cases each of secretory and proliferative endometrium.Results: A substantial increase in expression of Cyclin D1 was seen in hyperplastic endometrium compared to normal endometrium. Moreover, complex hyperplasia showed the maximum positivity for Cyclin D1.Conclusions: Cyclin D1 may play a stimulatory role in the proliferation of endometrial glands and hence may be involved in endometrial tumorigenesis.en_US
dc.identifier.affiliationsDepartment of Pathology, Bhagat Phool Singh Government Medical College for Women, Khanpur Kalan, Sonepat, Haryana, Indiaen_US
dc.identifier.citationKundu Parveen R., Sindhu Anjali, Kaur Swaran, Kulhria Amrita, Hooda Ritika. Expression of Cyclin D1 in normal and hyperplastic endometrium. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2019 Nov; 8(11): 4474-4478en_US
dc.identifier.issn2320-1770
dc.identifier.issn2320-1789
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/207180
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber11en_US
dc.relation.volume8en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-1770.ijrcog20194878en_US
dc.subjectCyclin D1en_US
dc.subjectEndometriumen_US
dc.subjectHyperplasiaen_US
dc.titleExpression of Cyclin D1 in normal and hyperplastic endometriumen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijrcog2019v8n11p4474.pdf
Size:
616.29 KB
Format:
Adobe Portable Document Format
Download
Collections
International Journal of Reproduction, Contraception, Obstetrics and Gynecology