Neuropsychiatric manifestations in Thai patients with systemic lupus erythematosus.
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2002-09-18
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Abstract
Neuropsychiatric (NP) manifestations in patients with systemic lupus erythematosus (SLE) [NPSLE] and prognostic factors were studied in 91 patients. There were 98 NP episodes, of which 78 (79.6%) occurred within the first year of the disease. Twenty-six patients (6.7%) had NPSLE as an initial presentation of the disease. There were seizures in 53 episodes (54.1%), psychosis in 13 (13.3%), acute confusion state in 11 (11.2%), abnormal consciousness in 6 (6.1%), transverse myelitis in 6 (6.1%), peripheral neuropathy in 5 (5.1%), cerebral infarction in 2 (2.0%) and aseptic meningitis in 2 (2.0%). Most forms of NPSLE responded well to high dose corticosteroids. Anti-convulsant therapy could be discontinued within a median duration of 3 months after the SLE activity was under control, and without significant recurrence of seizures. The 5-year and 10-year survival rates of patients with NPSLE were 75.9% and 50.6%, respectively. Patients with NPSLE had significantly more cutaneous vasculitis and less arthritis than those without.
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Published by the Allergy and Immunology Society of Thailand.
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Citation
Kasitanon N, Louthrenoo W, Piyasirisilp S, Sukitawu W, Wichainun R. Neuropsychiatric manifestations in Thai patients with systemic lupus erythematosus. Asian Pacific Journal of Allergy and Immunology. 2002 Sep; 20(3): 179-85