HIV-associated non-Hodgkin's lymphoma: Experience from a regional cancer center.

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dc.contributor.authorSharma, A
dc.contributor.authorBajpai, J
dc.contributor.authorRaina, V
dc.contributor.authorMohanti, B K
dc.date.accessioned2013-01-11T07:40:02Z
dc.date.available2013-01-11T07:40:02Z
dc.date.issued2010-01
dc.description.abstractAims : To analyze clinical features and survival in HIV-associated non-Hodgkin lymphoma (NHL) cases registered at Dr BRA Institute Rotary Cancer Hospital of AIIMS, New Delhi. Materials and Methods : We have retrospectively reviewed records of NHL patients registered, from January 2003 to July 2007 to analyze HIV-associated NHL. Results : Seven cases of HIV-associated NHL cases were identified. Age range was 14-56 years. Five were males. Baseline performance status (ECOG-PS) was >I in 6. Mean LDH was 409 U/L. Mean hemoglobin was 10.5 g% and mean CD4 count was 243/mm3 (range 18- 454). Three cases had nodal lymphoma and four had extra nodal lymphoma. No primary CNS (PCNSL) lymphoma was seen. All patients were of advanced stages and of intermediate to high-risk group based on international prognostic index (IPI). Six cases had high-grade NHL. None had CNS involvement. Five had B symptoms. HIV infection was diagnosed as part of NHL work-up in five patients. All patients received HAART. All were planned for chemotherapy with CNS prophylaxis. Protocols used were CVP, CHOP, R-CHOP or MCP-842. One patient received IFRT. Response : One patient achieved complete response (CR) and continues to be disease free, with 4.5 years of follow-up. Three cases achieved partial response (PR) and 2 had progressive disease (PD). Currently, three patients are on follow-up. Conclusions : These NHL are of higher grade and advanced stage. Response and tolerance to chemotherapy is poor. Appropriate supportive care and CNS prophylaxis might improve outcome. We need to improve epidemiological data collection system in this part of world. With HAART, the goal of therapy is durable CR rather than palliation.en_US
dc.identifier.citationSharma A, Bajpai J, Raina V, Mohanti B K. HIV-associated non-Hodgkin's lymphoma: Experience from a regional cancer center. Indian Journal of Cancer. 2010 Jan-Mar; 47(1): 35-39.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/144291
dc.language.isoenen_US
dc.source.urihttps://www.indianjcancer.com/article.asp?issn=0019-509X;year=2010;volume=47;issue=1;spage=35;epage=39;aulast=Sharmaen_US
dc.subjectAcquired immune deficiency syndromeen_US
dc.subjecthuman immunodeficiency virusen_US
dc.subjectnon-Hodgkin lymphomaen_US
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols
dc.subject.meshAntiretroviral Therapy, Highly Active
dc.subject.meshFemale
dc.subject.meshHIV Infections --complications
dc.subject.meshHIV Infections --drug therapy
dc.subject.meshHIV Infections --mortality
dc.subject.meshHumans
dc.subject.meshLymphoma, AIDS-Related --drug therapy
dc.subject.meshLymphoma, AIDS-Related --mortality
dc.subject.meshLymphoma, AIDS-Related --pathology
dc.subject.meshLymphoma, Non-Hodgkin --drug therapy
dc.subject.meshLymphoma, Non-Hodgkin --mortality
dc.subject.meshLymphoma, Non-Hodgkin --virology
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshNeoplasm Staging
dc.subject.meshRetrospective Studies
dc.subject.meshYoung Adult
dc.titleHIV-associated non-Hodgkin's lymphoma: Experience from a regional cancer center.en_US
dc.typeArticleen_US
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