Comparison in pathological behaviours & prognosis of gastric cancers from general hospitals between China & Japan.

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dc.contributor.authorYu, Miao
dc.contributor.authorZheng, Hua-chuan
dc.contributor.authorXia, Pu
dc.contributor.authorTakahashi, Hiroshi
dc.contributor.authorMasuda, Shinji
dc.contributor.authorTakano, Yasuo
dc.contributor.authorXu, Hui-mian
dc.date.accessioned2011-12-01T05:27:53Z
dc.date.available2011-12-01T05:27:53Z
dc.date.issued2010-09
dc.description.abstractBackground & objective: Gastric cancer is the fourth most common cancer and the second leading cause of cancer-related deaths after lung carcinoma. The aim of this study was to understand the difference in clinicopathological behaviours and prognosis of gastric cancer in patients from China and Japan. Methods: Paraffin-fixed tissue samples of gastric cancer were collected retrospectively from two hospitals between 1993 to 2006 in Japan (n=2063) and during 1980-2003 in China (n=2496) respectively, and staging was done by TNM system and typing by Japanese Endoscopy Society criteria or Borrmann’s classification. The histological architecture of the tumours was expressed according to Lauren’s classification. Results: Compared to Japan, the occurrence of gastric cancer was more common in younger Chinese population and prone to invasion and metastasis in muscularis propia, lymphatic, lymph node, liver, peritoneal parts, and exhibited large tumour size and high TNM staging in both the sexes and in different age groups (P<0.05). Intestinal and mixed types of carcinomas were more frequently observed in Japanese patients compared to Chinese and the difference was significant (P<0.05). It was observed that the commonly reported types in early gastric cancers (EGC) in Japanese patients were IIc, IIa+IIc or IIa while those of Chinese patients were IIc, III or IIb. In the case of advanced gastric cancers (AGC), type II and III were most common in both the countries. The cumulative survival rate of Chinese patients was significantly (P<0.05) higher compared to Japanese in different stratified groups via depth of invasion, TNM staging or Lauren’s classification. Interpretation & conclusion: Gastric cancers in Chinese patients had more aggressive pathological characteristics and poorer prognosis than those from Japan. To reduce incidence and to improve treatment facilities, it is necessary to have a systematic screening system.en_US
dc.identifier.citationYu Miao, Zheng Hua-chuan, Xia Pu, Takahashi Hiroshi, Masuda Shinji, Takano Yasuo, Xu Hui-mian. Comparison in pathological behaviours & prognosis of gastric cancers from general hospitals between China & Japan. Indian Journal of Medical Research. 2010 Sept; 132(3): 295-302.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/135583
dc.language.isoenen_US
dc.source.urihttps://icmr.nic.in/ijmr/2010/september/0910.pdfen_US
dc.subjectChinaen_US
dc.subjectgastric canceren_US
dc.subjectJapanen_US
dc.subjectpatholobiological behavioursen_US
dc.subjectprognosisen_US
dc.subject.meshAge Factors
dc.subject.meshChina --epidemiology
dc.subject.meshFemale
dc.subject.meshHistological Techniques
dc.subject.meshHumans
dc.subject.meshIncidence
dc.subject.meshJapan --epidemiology
dc.subject.meshMale
dc.subject.meshNeoplasm Staging --statistics & numerical data
dc.subject.meshPrognosis
dc.subject.meshRetrospective Studies
dc.subject.meshStatistics, Nonparametric
dc.subject.meshStomach Neoplasms --classification
dc.subject.meshStomach Neoplasms --epidemiology
dc.subject.meshStomach Neoplasms --mortality
dc.subject.meshStomach Neoplasms --pathology
dc.titleComparison in pathological behaviours & prognosis of gastric cancers from general hospitals between China & Japan.en_US
dc.typeArticleen_US
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